MedChem Express (MCE) - New Products 2023
Learn about the latest products from MedChemExpress (MCE), including high-quality bio/chemicals for research, novel bioactive compounds, dye reagents, peptides and natural compounds for research use.
- Over 50’000 bioactive molecules in stock
- Target 500+ key proteins in 20+ signaling pathways
- Quality reports (LC/MS, NMR and HPLC) for each product
- Release of more than 1’000 newest biochemicals per month
- Data sheet with detailed biological information
- High purity & competitive prices
February 2023: MCE New Products
Dalazatide TFA
Kv1.3 Inhibitor/Inflammatory Diseases
- A specific Kv1.3 potassium channel peptide inhibitor.
- Used in the study of autoimmune diseases such as multiple sclerosis.
- Inhibits delayed-type hypersensitivity, suppresses the motility and activation of Tem cells in vivo.
Amivantamab
CAS-No: 2171511-58-1
EGFR-MET Antibody/Immune Anticancer
- Inhibits ligand binding, promotes endocytosis and degradation of receptor-antibody complexes.
- Induces Fc-dependent cytokinesis in macrophages and antibody-dependent cytotoxicity in natural killer cells.
- Exhibits anti-cancer activity in EGFR exon 20 insertion-driven NSCLC models.
Midaglizole
CAS-No: 66529-17-7
α2-Adrenoceptor Antagonist/Blood Pressure/Blood Glucose
- A potent α2-adrenoceptor antagonist.
- Stimulates insulin release in vitro.
- Increases blood pressure and reduces blood glucose levels in vivo.
- Solubility: DMSO : 162.5 mg/mL (ultrasonic)
SK-575
CAS-No: 2523016-96-6
PROTAC PARP1 Degrader/Cancer
- A highly potent and specific PROTAC degrader of PARP1.
- Exhibits significant antitumor activity in breast cancer models
- Solubility: DMSO : 200 mg/mL (228.06 mM; Need ultrasonic)
RBN-3143
CAS-No: 2360853-16-1
PARP14 Inhibitor/Inflammatory Diseases
- A selective PARP14 inhibitor with an IC50 value of 4 nM.
- Inhibits PARP14-mediated ADP-ribosylation and stabilizes PARP14 in cells.
- Used in research of inflammation. Improves steroid-resistant asthma in vivo
- Solubility: DMSO : 12.5 mg/mL (27.81 mM; ultrasonic and warming and heat to 80°C)
February 2023: Latest Publications Citing Use of MCE Products
Nature. 2023 Jan;613(7942):187-194.
Nature. 2022 Dec;612(7941):725-731.
Nature. 2023 Jan;613(7942):145-152.
Nature. 2023 Jan;613(7942):120-129.
Immunity. 2023 Jan 10;56(1):180-192.e11.
January 2023: MCE New Products
EEDi-5285
CAS-No: 2488952-40-3
EED Inhibitor/Lymphoma
- A potent and orally active embryonic ectoderm development (EED) inhibitor with an IC50 of 0.2 nM
- Efficaciously inhibits Pfeiffer and KARPAS422 lymphoma cancer cells with IC50 values of 20 pM and 0.5 nM, respectively
- Significantly induces tumor regression in KARPAS422 xenograft mouse models
- Solubility: DMSO, 125 mg/mL (260.67 mM; Need ultrasonic)
Cadisegliatin
CAS-No: 859525-02-3
Glucokinase Activator/Type 1 and 2 Diabetes
- An orally active and liver-selective glucokinase (GK) activator
- Increases glucose metabolism in rat hepatocytes with EC50 values of 2.39 μM and 2.64 μM for lactate and glycogen, respectively
- Reduces blood glucose, lactate and triglyceride concentrations in ob/ob mouse models with severe diabetes
- Solubility: DMSO 125 mg/mL (274.35 mM; Need ultrasonic)
A-317567
CAS-No: 371217-32-2
ASIC-3 Inhibitor/Depression and Pain
- A potent acid-sensing ion channel 3 (ASIC-3) inhibitor with an IC50 of 1.025 μM
- Dose-dependently inhibits all ASIC currents (IC50s of 2-30 µM)
- Shows fully analgesic effects in Complete Freund’s adjuvant (CFA)-induced inflammatory thermal hyperalgesia rat models
- Solubility: DMSO 125 mg/mL (314.42 mM; Need ultrasonic)
BMS-984923
CAS-No: 1375752-78-5
mGluR5 Silent Allosteric Modulator/Alzheimer's Disease
- An orally active and BBB penetrable mGluR5silent allosteric modulator (SAM) with a Ki value of 0.6 nM
- Prevents amyloid-β oligomer (Aβo) mediated toxicity and Aβo-induced signal transduction in brain slices
- Rescues memory deficits and synaptic depletion in Alzheimer’s disease transgenic mouse models
- Solubility: DMSO 100 mg/mL (266.79 mM; Need ultrasonic)
January 2023: Latest Publications Citing Use of MCE Products
Nature. 2022 Dec;612(7940):555-563.
Science. 2022 Dec 2;378(6623):eabo5503.
Cell. 2022 Nov 10;185(23):4347-4360.e17.
Cell. 2022 Dec 8;185(25):4801-4810.e13.
