MedChem Express (MCE) - New Products January 2023

Learn about the latest products from MedChemExpress (MCE), including high-quality bio/chemicals for research, novel bioactive compounds, dye reagents, peptides and natural compounds for research use.

  • Over 50’000 bioactive molecules in stock
  • Target 500+ key proteins in 20+ signaling pathways
  • Quality reports (LC/MS, NMR and HPLC) for each product
  • Release of more than 1’000 newest biochemicals per month
  • Data sheet with detailed biological information
  • High purity & competitive prices

EEDi-5285

CAS-No: 2488952-40-3

EED Inhibitor/Lymphoma

  • A potent and orally active embryonic ectoderm development (EED) inhibitor with an IC50 of 0.2 nM
  • Efficaciously inhibits Pfeiffer and KARPAS422 lymphoma cancer cells with IC50 values of 20 pM and 0.5 nM, respectively
  • Significantly induces tumor regression in KARPAS422 xenograft mouse models
  • Solubility: DMSO, 125 mg/mL (260.67 mM; Need ultrasonic)

Cadisegliatin

CAS-No: 859525-02-3

Glucokinase Activator/Type 1 and 2 Diabetes

  • An orally active and liver-selective glucokinase (GK) activator
  • Increases glucose metabolism in rat hepatocytes with EC50 values of 2.39 μM and 2.64 μM for lactate and glycogen, respectively
  • Reduces blood glucose, lactate and triglyceride concentrations in ob/ob mouse models with severe diabetes
  • Solubility: DMSO 125 mg/mL (274.35 mM; Need ultrasonic)

A-317567

CAS-No: 371217-32-2

ASIC-3 Inhibitor/Depression and Pain

  • A potent acid-sensing ion channel 3 (ASIC-3) inhibitor with an IC50 of 1.025 μM
  • Dose-dependently inhibits all ASIC currents (IC50s of 2-30 µM)
  • Shows fully analgesic effects in Complete Freund’s adjuvant (CFA)-induced inflammatory thermal hyperalgesia rat models
  • Solubility: DMSO 125 mg/mL (314.42 mM; Need ultrasonic) 

BMS-984923

CAS-No: 1375752-78-5

mGluR5 Silent Allosteric Modulator/Alzheimer's Disease

  • An orally active and BBB penetrable mGluR5silent allosteric modulator (SAM) with a Ki value of 0.6 nM
  • Prevents amyloid-β oligomer (Aβo) mediated toxicity and Aβo-induced signal transduction in brain slices
  • Rescues memory deficits and synaptic depletion in Alzheimer’s disease transgenic mouse models
  • Solubility: DMSO 100 mg/mL (266.79 mM; Need ultrasonic) 

Latest Publications Citing Use of MCE Products

Nature. 2022 Dec;612(7940):555-563. 
Science. 2022 Dec 2;378(6623):eabo5503. 
Cell. 2022 Nov 10;185(23):4347-4360.e17. 
Cell. 2022 Dec 8;185(25):4801-4810.e13. 

Browse the newest MCE small molecules by research area