MedChem Express (MCE) - New Products 2024

Learn about the latest products from MedChemExpress (MCE), including more than 100,000 bioactive compounds, dye reagents, peptides and natural compounds for laboratory and scientific use.

Over 100’000 bioactive molecules in stock
Target 1000+ key proteins in 20+ signaling pathways
Quality reports (LC/MS, NMR and HPLC) for each product
Release of more than 1’000 newest biochemicals per month
Data sheet with detailed biological information
High purity & competitive prices

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New Products May 2024

New Bioactive Molecules for April 2024

CAS No.: 2745060-92-6

INX-315

Research Area: CDK/CDK2/Cancer

•	An orally active and selective CDK2 inhibitor with an IC₅₀ of 0.6 nM for CDK2/cyclin E.
•	Induces cell cycle arrest and therapy-induced senescence in solid tumors.
•	Demonstrates robust antitumor activity in CCNE1-amplified cancers.
•	Solubility: DMSO: 100 mg/mL (233.93 mM; Need ultrasonic)

CAS No.: 325457-99-6

ICA 110381

Research Area: Potassium Channel/Neurological Disease

•	An orally active K_v7.2/K_v7.3 (KCNQ2/3) potassium channel activator with an EC₅₀ of 0.38 μM.
•	Shows anticonvulsive properties in fully amygdala-kindled rats.
•	Solubility: DMSO: 125 mg/mL (467.97 mM; Need ultrasonic)

CAS No.: 195615-83-9

Blarcamesine

Research Area: Sigma Receptor/mAChR/Neurological Disease

•	An orally active Sigma-1 receptor (σ1-receptor) and M1 mAChR agonist.
•	Prevents Aβ_25-35-induced increases in lipid peroxidation levels and mitochondrial respiratory dysfunction.
•	Used for the research in Alzheimer's disease and Rett syndrome.
•	Solubility: DMSO: 125 mg/mL (444.22 mM; Need ultrasonic)

Immunomagnetic Beads for Cell Separation

MCE provides more convenient and rapid cellsorting kits, use MACS MicroBeads. The separated cells have high purity and good biological activity.

Positive Selection Kits

Mouse CD4⁺ Cell Positive Selection Kit

Mouse CD8⁺ Cell Positive Selection Kit

Negative Selection Kits

Mouse CD3⁺ T Cells Negative Selection Kit

Mouse CD4⁺ T Cells Negative Selection Kit

Mouse CD8⁺ T Cells Negative Selection Kit

Human CD3⁺ T Cells Negative Selection Kit

Human CD34⁺ Cells Negative Selection Kit

Food Contaminant Toxicity

Common food pollutants include toxins, alkaloids, etc.

Product Name	Description
Ochratoxin C	A mycotoxin, is commonly found as a food contaminant.
Citrinin	A mycotoxin, causes contamination in the food and is associated with different toxic effects.
Retrorsine	Binds with DNA and inhibits the proliferative capacity of hepatocytes. And can be used for the research of hepatocellular injury.
Seneciphylline	A toxic pyrrolizidine alkaloid.

MCE Compound Library

Provides a professional compound library to serve research in multiple fields including cancer.

Product Name	Description
Radioprotector Library	Prevent/protect non-tumor cells from the harmful effects of radiation. Contains 1,700+ radioprotector compounds, can be for radiation diseases and radiotherapy drugs.
Radiosensitizer Library	Enhance the radiosensitivity of tumor cells and improve the effect of radiotherapy. Contains 40+ radiosensitizers that can be used in combination drug administration research in cancer treatment.

Latest Publications Citing Use of MCE Products
	Nature. 2024 Apr;628(8007):408-415.
	Nature. 2024 Apr;628(8006):145-153.
	Cell. 2024 Mar 28;187(7):1701-1718.e28.
	Science. 2024 Mar 22;383(6689):eadj4591.

New Products April 2024

New Bioactive Molecules for April 2024

CAS No.: 1421854-16-1

AC-186

Research Area: Estrogen Receptor/ERR/Neurological Disease

•	A selective non-steroidal estrogen receptor β (ERβ) agonist with EC₅₀ values of 6 nM and 5000 nM for ERβ and ERα, respectively.
•	Exhibits gender selective neuroprotective effects in a male rat model of Parkinson's disease.
•	Solubility: DMSO: 100 mg/mL (326.46 mM; Need ultrasonic)

CAS No.: 216227-54-2

ONT-093

Research Area: P-glycoprotein/Cancer

•	An orally active P-glycoprotein (P-gp) inhibitor with an IC₅₀ of 160 nM.
•	Inhibits P-gp and reverse multidrug resistance at nM concentrations with no effect on Paclitaxel pharmacokinetics.
•	Solubility: DMSO: 100 mg/mL (202.15 mM; Need ultrasonic)

CAS No.: 1443748-47-7

VU0469650

Research Area: mGluR/Neurological Disease

•	A selective and brain-penetrant mGlu1 receptor negative allosteric modulator, exhibits >100-fold selectivity for mGlu1 over mGlu2-8.
•	Inhibits Glutamate-induced calcium flux in cells expressing human mGluR1 with an IC₅₀ of 99 nM.
•	Solubility: DMSO: 41.67 mg/mL (114.33 mM; Need ultrasonic and warming and heat to 60°C)

Animal-Free Recombinant Proteins

Animal-free means that no animal-derived material is involved in the production process. Animal-free recombinant proteins have the same biological activity as proteins produced using standard laboratory techniques.
MCE offers 200+ animal-free recombinant proteins for various research areas. Compared with traditional recombinant proteins, animal-free recombinant proteins have the following advantages.
1. No introduction of animal-derived pathogens into the culture system
2. No xenobiotic rejection or allergic reactions in animals or humans
3. No ethical and moral issues

Classification	Product Name
Interleukins	Animal-Free IL-6, Human
Interleukins	Animal-Free IL-4, Human
TNF Superfamily	Animal-Free TNF-alpha/TNFSF2, Human
FGF Family	Animal-Free FGF basic/bFGF, Human
EGF Superfamily	Animal-Free EGF, Human
CD Antigens	Animal-Free CD70, Mouse
Chemokines	Animal-Free MIP-1 alpha/CCL3, Mouse
BMPs	Animal-Free BMP-2, Human

Anti-Aging Natural Products

Aging is an unavoidable process, leading to cell senescence due to physiochemical changes in an organism. The purpose of anti-aging activities is to increase the life span and the quality of life. Anti-aging activities are primarily involved in the therapies of age-related disorders such as Parkinson's Disease (PD), Alzheimer's Disease (AD), cardiovascular diseases, cancer, and chronic obstructive pulmonary diseases. Natural products are known as effective molecules to delay the aging process through influencing metabolic pathways and thus ensure an extended lifespan.

Product Name	Description
Isofalcarintriol	A NRF2 activator and a selective mitochondrial ATP synthase inhibitor. A potent promoter of longevity in the nematode C. elegans.
24-Methylenecholesterol	A natural marine sterol, possess anti-aging effects in yeast.
Oleuroside	Protecting against mitochondrial dysfunction in models of early Alzheimer's disease and brain aging.
Epifriedelanol	Slowing the aging of human skin fibroblasts.
Boeravinone B	Acting as an anti-aging and anti-apoptosis phyto-molecule during oxidative stress.

MCE Compound Library

Provides a professional compound library to serve research in multiple fields including cancer, metabolism, etc.

Product Name	Description
Metabolic Enzyme Compound Library	As catalysts in metabolism, metabolic enzymes play an important role in organism metabolism, and their dysfunction can lead to the occurrence of various metabolic diseases. Containing 2,800+ metabolic enzyme compounds, which can be widely used in the study of metabolic diseases.
Antibody Inhibitor Library	In drug screening, antibody inhibitor-based screening can identify active compounds that target the target proteins and target diseases. Containing antibody inhibitors, which can be used for drug development in cancer, immunity, infection and other hot research areas.

Latest Publications Citing Use of MCE Products
	Nat Med. 2023 Mar;29(3):632-645.
	Nature. 2024 Mar;627(8002):149-156.
	Cell. 2024 Feb 29;187(5):1223-1237.e16.
	Science. 2024 Feb 2;383(6682):eadh4859.

New Products February 2024

New Bioactive Molecules for February 2024

CAS No.: 147030-48-6

KB130015

Research Area: Potassium Channel/Thyroid Hormone Receptor/Cardiovascular Disease

•	An orally active antiarrhythmic agent and a derivative of Amiodarone.
•	A hERG1 (K_v11.1) potassium channels activator, blocking native and recombinant hERG1 channels at high voltages, but activating them at low voltages.
•	A human thyroid hormone receptor α (ThRα) and ThRβ antagonist.
	Solubility: DMSO : 100 mg/mL (182.45 mM; Need ultrasonic)

CAS No.: 1345964-89-7

ML154

Research Area: Neuropeptide Y Receptor/Neurological Disease

•	A selective, brain-penetrant and non-peptide neuropeptide S receptor (NPSR) antagonist with a pA₂ of 9.98.
•	Potently inhibits NPS-stimulated cellular calcium, cAMP, and ERK phosphorylation responses with IC₅₀ values of 36.5 nM, 22.1 nM, and 9.3 nM, respectively.
•	Decreases alcohol self-administration in vivo, and has the potential for the alcoholism research.
	Solubility: DMSO : 62.5 mg/mL (114.58 mM; Need ultrasonic)

CAS No.: 2489226-14-2

AZD4747

Research Area: Ras/KRAS^G12C/Cancer

•	A selective, brain-penetrant and orally active mutant GTPase KRAS^G12C inhibitor with an IC₅₀ of 15 nM.
•	Shows highly selective for reaction with the cysteine in KRAS^G12C and has a selective antiproliferative phenotype in cancer cells bearing the G12C mutation.
•	Used for the research in KRAS^G12C-positive tumors, including central nervous system (CNS) metastases.
	Solubility: DMSO : 250 mg/mL (567.03 mM; Need ultrasonic)

CAS No.: 2998-57-4

Estramustine

Research Area: Microtubule/Tubulin/Prostate Cancer

•	An orally active antimicrotubule, alkylating, and antineoplastic agent, depolymerizes microtubule-associated proteins (MAPs) by binding to tubulin.
•	An Estradiol derivative with a nitrogen mustard moiety that selectively binds to active estrogen receptors.
•	Exhibits antimitotic activity in DU 145 cells, and has the potential for the prostate cancer research.
	Solubility: DMSO : 100 mg/mL (227.07 mM; Need ultrasonic)

Natural Products as Vaccine Adjuvants

Vaccine adjuvants are used to enhance the immune stimulating and therapeutic effect of cancer vaccines. In previous studies, natural products as vaccine adjuvants have been shown to effectively enhance immune stimulation and reverse immune suppression induced by related factors and cells. Among them, saponins, polysaccharides, and flavonoids are three major natural products with the potential to be developed as qualified adjuvants for cancer vaccines.

Product Name	CAS	Description
QS-21	141256-04-4	An immunostimulating saponin vaccine adjuvant. QS-21 stimulates Th2 humoral and Th1 cell-mediated immune responses through action on antigen presenting cells (APCs) and T cells.
Ginsenoside Rg1	22427-39-0	One of the major active components of Panax ginseng, ameliorating the impaired cognitive function, displays promising effects by reducing cerebral Aβ levels.
Curcumin	458-37-7	A specific inhibitor of acetyltransferase p300/CREB binding protein that inhibits the acetylation of histone/non-histone proteins. It has various pharmacological effects such as anti-inflammatory, antioxidant, anti-proliferation and anti-angiogenesis.
λ-Carrageenan	9064-57-7	A seaweed polysaccharide vaccine adjuvant that is widely used as a pro-inflammatory agent and anti-tumor active molecule.
Rutin	153-18-4	A flavonoid vaccine adjuvant widely present in a variety of plants, it has multiple biological activities such as anti-inflammatory, hypoglycemic, antioxidant, neuroprotective, renal protection, liver protection and reducing Aβ oligomer activity.
Naringenin	480-41-1	A potent vaccine adjuvant with potent anti-inflammatory and antioxidant activities.

MCE Compound Library

Provides a professional compound library to serve research in multiple fields including cancer.

Product Name	Size	Description
Anti-Drug-Resistant Compound Library	300+	Drug resistance problem has long affected the development of anticancer drugs. Anti-drug resistance compounds can be widely used in research to overcome multidrug resistance in cancer treatment.
Allosteric Modulators (AMs) Compound Library	160+	Allosteric modulators (AMs) change the conformation of biological targets by binding to secondary allosteric sites, thereby affecting their biological activity. Allosteric modulators can be used as tool compounds for research on metabolism, cancer and other diseases.

Latest Publications Citing Use of MCE Products
	Cell. 2024 Jan 4;187(1):44-61.e17.
	Cell.2023 Nov 22;186(24):5347-5362.e24.
	Cell. 2024 Jan 4;187(1):166-183.e25.
	Cancer Cell. 2024 Jan 8;42(1):135-156.e17.