Anti-CD8 Monoclonal Antibody (Clone:MEM-31)-PerCP Conjugated
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The CD8 T cell coreceptor (monomer approx. 32-34 kDa) is expressed as alpha/beta heterodimer on majority of MHC I-restricted conventional T cells and thymocytes and as alpha/alpha homodimer on subsets of memory T cells, intraepithelial lymphocytes, NK cells and dendritic cells. Regulation of CD8 beta level on T cell surface seems to be an important mechanism to control their effector function. Assembly of CD8 alpha-beta but not alpha-alpha dimers is connected with formation or localization to the lipid rafts. Recruiting triggered TCR complexes to these membrane microdomains as well as affinity of TCR to MHC I is modulated by CD8, thereby affecting the functional diversity of the TCR signaling.
|Immunogen||Crude thymus membrane fraction.|
|Storage Conditions||Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light.|
|Tech. Data Sheet||View datasheet|
|Link To Supplier||https://www.abeomics.com|
|Shipping Details||Blue Ice|
|Material Safety Data Sheet||Download PDF|