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IDH889


Catalog Number Pack Size List Price* Quantity
HY-112289-5MG 5 mg Inquire
HY-112289-25MG 25 mg Inquire
HY-112289-10MG 10 mg Inquire
HY-112289-50MG 50 mg Inquire
HY-112289-100MG 100 mg Inquire

* CHF, excl. 7.7% VAT and shipping costs


Product Description

IDH889 is an orally available, brain penetrant, allosteric and mutant specific inhibitor of isocitrate dehydrogenase 1 (IDH1). IDH889 has potent selectivity for IDH1 R132* mutations, with IC50s of 0.02 μM, 0.072 μM and 1.38 μM for IDH1R132H, IDH1R132C and IDH1wt, respectively. IDH889 shows potent cellular inhibition of R-2-hydroxyglutarate (2-HG) production with an IC50 of 0.014 μM.

Category Biochemicals
Supplier MedChem Express
Application Cancer-programmed cell death
Regulatory Status RUO
Grade Clinical information: No Development Reported
Molecular Formula C23H25FN6O2
Molecular Weight 436.48
CAS-Number [1429179-07-6]
Storage Conditions Please store the product under the recommended conditions in the Certificate of Analysis.
Product Line Research
Tech. Data Sheet View datasheet
Link To Supplier http://www.medchemexpress.com
Material Safety Data Sheet Download PDF
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