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bpV(phen) trihydrate, a insulin-mimetic agent, is a potent protein tyrosine phosphatase (PTP) and PTEN inhibitor with IC50s of 38 nM, 343 nM and 920 nM for PTEN, PTP-β and PTP-1B, respectively. bpV(phen) trihydrate inhibits proliferation of the protozoan parasite Leishmania in vitro. bpV(phen) trihydrate strongly induces the secretion of a large number of chemokines and pro-inflammatory cytokines, and it activates a Th1-type pathway (IL-12, IFNγ). bpV(phen) trihydrate can also induce cell apoptosis, and has anti-angiogenic and anti-tumor activity.
|Format||Solubility: H2O : 18.18 mg/mL (44.97 mM; Need ultrasonic)|
|Grade||Clinical information: No Development Reported|
|Storage Conditions||Powder -20°C 3 years, 4°C 2 years; In solvent -80°C 6 months, -20°C 1 month|
|Tech. Data Sheet||View datasheet|
|Link To Supplier||http://www.medchemexpress.com|
|Material Safety Data Sheet||Download PDF|