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Bractoppin


Catalog Number Pack Size List Price* Promo Price* Quantity
HY-126020-5MG 5 mg 181,00 153,90 Add
HY-126020-10MMO 10 mM * 1 mL 197,00 167,50 Add
HY-126020-10MG 10 mg 299,00 254,20 Add
HY-126020-25MG 25 mg 656,00 557,60 Add
HY-126020-50MG 50 mg 935,00 794,80 Add
HY-126020-100MG 100 mg 1'485,00 1'262,30 Add

* CHF, excl. 7.7% VAT and shipping costs


Product Description

Bractoppin is a potent and selective drug-like inhibitor of phosphopeptide recognition by the human BRCA1 tandem(t) BRCT domain (binding IC50: 74 nM). Bractoppin diminishes BRCA1 recruitment to DNA breaks, in turn suppressing damage-induced G2 arrest and assembly of the recombinase, RAD51. Bractoppin preferentially inhibits BRCA1 tBRCT-dependent steps in the DNA damage response.

Category Biochemicals
Supplier MedChem Express
Application Cancer-programmed cell death
Regulatory Status RUO
Format Solubility: DMSO : 250 mg/mL (603.18 mM; Need ultrasonic)
Grade Clinical information: No Development Reported
Molecular Formula C25H23FN4O
Molecular Weight 414.47
CAS-Number [2290527-07-8]
Storage Conditions Powder -20°C 3 years, 4°C 2 years; In solvent -80°C 6 months, -20°C 1 month
Product Line Research
Tech. Data Sheet View datasheet
Link To Supplier http://www.medchemexpress.com
Material Safety Data Sheet Download PDF
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