FNDR-20123
| Catalog Number | Pack Size | List Price* | Quantity | |
|---|---|---|---|---|
| HY-131708A-5MG | 5 mg | 495,00 | Add | |
| HY-131708A-10MMO | 10mM/1mL | 543,00 | Add | |
| HY-131708A-10MG | 10 mg | 773,00 | Add | |
| HY-131708A-25MG | 25 mg | 1'470,00 | Add | |
| HY-131708A-50MG | 50 mg | 2'294,00 | Add | |
| HY-131708A-100MG | 100 mg | 3'624,00 | Add | |
| HY-131708A-S-1ST | Sample | Inquire |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
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FNDR-20123 is a safe, first-in-class, and orally active anti-malarial HDAC inhibitor with IC50s of 31 nM and 3 nM for Plasmodium and human HDAC, respectively. FNDR-20123 exerts anti-malarial activity against Plasmodium falciparum asexual stage (IC50=41 nM) and sexual blood stage (IC50=190 nM for male gametocytes). FNDR-20123 inhibits HDAC1, HDAC2, HDAC3, HDAC6, and HDAC8 (IC50=25/29/2/11/282 nM, respectively.) and inhibits Class III HDAC isoforms at nanomolar concentrations[1].
| Category | Biochemicals |
| Supplier | MedChem Express |
| Regulatory Status | RUO |
| Research Field | Infection, Anti-infection,Cell Cycle/DNA Damage,Epigenetics |
| Format | Solubility: DMSO : 31.25 mg/mL (ultrasonic) |
| Grade | Clinical information: No Development Reported |
| Purity | 98.08% |
| Molecular Formula | C21H24ClN5O2 |
| Molecular Weight | 413.9 |
| CAS-Number | 2641930-61-0 |
| Storage Conditions | 4°C (Powder, sealed storage, away from moisture) |
| Tech. Data Sheet | View datasheet |
| Link To Supplier | http://www.medchemexpress.com |
| Shipping Details | Room Temperature |
| Material Safety Data Sheet | Download PDF |
