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YUM70 is a potent and selective inhibitor of glucose-regulated protein 78 (GRP78), with an IC50 of 1.5 μM for inhibiting GRP78 ATPase activity of the full-length protein. YUM70 induces endoplasmic reticulum (ER) stress-mediated apoptosis in pancreatic cancer. YUM70 also has in vivo efficacy in a pancreatic cancer xenograft model.
|Application||Cancer-programmed cell death|
|Format||Solubility: DMSO : 100 mg/mL (250.73 mM; Need ultrasonic)|
|Grade||Clinical information: No Development Reported|
|Storage Conditions||Powder -20°C 3 years, 4°C 2 years; In solvent -80°C 6 months, -20°C 1 month|
|Tech. Data Sheet||View datasheet|
|Link To Supplier||http://www.medchemexpress.com|
|Material Safety Data Sheet||Download PDF|