SignalChem Diagnostics Promotion
24% to 69% off Advanced CRISPR-Cas Systems
Quality Assured CRISPR Cas Enzymes, Kits and Reagents
Valid until 31st May 2025.
Not summable with other discounts.
SignalChem Diagnostics - Advanced CRISPR-Cas Systems
Precision Gene Editing with SignalChem Diagnostics
SignalChem Diagnostics provides a premium portfolio of highly active recombinant CRISPR-associated proteins and specialized kits and reagents, designed for advanced gene-editing applications. Their CRISPR enzymes deliver exceptional specificity, efficiency, and versatility, while their optimized reagents ensure enzyme stability and reliable performance—empowering the development of innovative and accurate gene-editing solutions.
Their portfolio encompasses both DNA- and RNA-targeting systems, featuring carefully engineered variants with distinct properties and capabilities.
Comprehensive Portfolio of Class 1 and 2 CRISPR Enzymes
SignalChem Diagnostics’ CRISPR Portfolio comprises Cas9, Cas12, Cas13, and Csm6 nucleases optimized for nucleic acid detection purposes. Their high-purity recombinant proteins are RNase- and DNase-free, rigorously tested, and functionally verified. To best support your research, they also provide glycerol-free versions of selected enzymes.
Quality Assurance
All enzymes undergo rigorous quality control testing to ensure high purity, stability, and specific activity; batch-to-batch consistency; and validated functionality in recommended applications.
DNA Targeting - Cas9 & Cas12
Cas9: Precise Targeting - Versatile Cleavage
- Multiple engineered variants for customizable DNA modification:
- Double-strand blunt cuts (CS09-E311H, CS09N-E312H with NLS)
- Strand-specific nicking capability (CS09N-E331H, CS09N-E332H)
- Target binding without cleavage (CS09N-E333H)
- Derived from Streptococcus pyogenes
- Simple 5′-NGG-3′ PAM requirement
Cas12: Enhanced DNA Targeting Flexibility
- Multiple orthologues for diverse experimental conditions:
- AsCas12a (CS12A-E311H): crRNA-only system
- LbCas12a (C12CR-E241G): Active at lower temperature
- FnCas12a (CF12A-E311HB): Broader PAM recognition
- AapCas12b (C12B1-E311U): Smaller size, requires both crRNA and tracrRNA
- Staggered cut pattern
- Collateral ssDNA cleavage activity useful for detection
RNA Targeting - Cas13 & Csm6
Cas13: RNA-Targeting Specialists
- Diverse variants for RNA manipulation and detection:
- LbuCas13a (CS13A-E322U) and LwCas13a (CS13A-E321H): RNA targeting
- TccCas13a (CS13A-E314H): Enhanced thermostability (37-70°C)
- CcaCas13b (CS13B-E311H) and PsmCas13b (CS13B-E312H): Structural and conformational differences
- Programmable RNA targeting with collateral activity
- Flexible protospacer flanking site requirements
Csm6: Advanced Type III-A System Components
- Two available variants:
- EiCsm6 (CS06-E312H): cyclic hepta-adenylate activating ligand
- TtCsm6 (CS06-E311H): cyclic tetra-adenylate activating ligand
- Complementary RNA degradation activity
- Can be used together with Cas13 to amplify detection signal from collateral cleavage
CRISPR Kits and Reagents
SignalChem Diagnostics offers a selection of specialized CRISPR kits and reagents designed to ensure optimal performance and stability of CRISPR-associated proteins in your gene-editing applications. CRISPR kits and reagents, including reaction and storage buffers, are carefully formulated to maintain enzyme activity, maximize efficiency, and ensure reliable results in CRISPR-based gene manipulation techniques.
