AcroBiosystems - Solutions from Discovery to the Clinic
Where Proteins and Innovation advance Biomedicine
AcroBiosystems is a trusted global leader in providing innovative, high-quality recombinant proteins, antibodies, assay kits, GMP-grade reagents, and custom services – empowering scientists and researchers to drive breakthrough discoveries in biologics and cell therapies.
ISO9001 and ISO13485 certified
Why Choose ACROBiosystems
Ensured natural conformation of the proteins
- 95% of the proteins are produced by HEK293 cells and make sure the proper protein folding.
- Avi™ Tag technology is used for biotin-labelled proteins and leads to high detect sensitivity.
- FLAG™ technology platforms for full length multi-pass transmembrane proteins to address the structural complexity of multi-pass TPs and meet the needs of different application.
- Star Staining™ technology platforms for fluorescent-labelled products, using new-generation site-specific labelling technology to maintain natural bioactivity.
- Guaranteed technology platforms for multi-pass transmembrane proteins, next-generation fluorescent site-directed labeling, and enzymology
Strict quality control systems
- ISO9001 and ISO13485 certified
- GMP quality management system
- SEC-MALS for validating purity and correct agglomerated structure in addition to HPLC and SDS-PAGE.
- ELISA/SPR/BLI/cell-based assay for validating bioactivity.
- Ensured batch to batch consistency.
- DMF (FDA) available for some products.
Featured ACROBiosystem Recombinant Protein Groups
CAR Target Proteins
ACROBiosystems has developed an extensive collection of recombinant proteins to support CAR-T therapy development. This growing list of proteins includes many fluorescent-labeled target antigens and pre-biotinylated proteins that are uniquely suitable for evaluation of CAR expression. In addition, we also supply difficult-to-express proteins such as BCMA, CD19, ROR1, and EGFRVIII.
Evaluation of Anti-BCMA CAR Expression with Biotinylated BCMA
Human T cells were transfected with anti-BCMA CAR and cultured for 3 days. Three days post-transfection, 1e6 cells were first incubated with 50 µl biotinylated human BCMA protein (Cat. No. BC7-H82F0, 8 µg/ml), washed and then stained with PE Streptavidin and analyzed by flow cytometry. (Data are kindly provided by PREGENE Biopharma)
GMP and Premium Grade (Pre-GMP) Proteins
Providing high-quality GMP products at an affordable cost can help lower the barrier in accessing innovative medicines including cell therapies. When transitioning from premium (Pre-GMP) grade products to GMP, there should be minimal comparability testing needed. ACROBiosystem’s premium-grade products have been validated to have equivalent bioactivity and consistency, and are manufactured using the same methods and processes.
ACROBiosystems is committed to the development of high-quality reagents for use in the clinical stage of immune cell therapy drugs. Based on the GMP-grade quality management system platform, combined with the production specifications of cell therapy drugs, they have successfully developed a series of high-quality GMP-grade proteins, including cytokines. These products are produced with strict quality management and drug-level release testing standards. Read more
GMP Grade Cytokines – GMP IL-15 Quality Data
Three independent lots of GMP Human IL-15 (Cat. No. GMP-L15H13) were tested for the ability to simulate the proliferation of CTLL-2 cells. Average specific activity of GMP Human IL-15 was defined to be more than 0.8 x 107 IU/mg after calibration against human IL-15 WHO International Standard (NIBSC code: 95/554).
Multi-pass Transmembrane Proteins
Unlock the Potential of Transmembrane Proteins for Drug Discovery
Transmembrane proteins (TPs) are vital for cellular communication and serve as key drug targets due to their role in signaling pathways. However, isolating full-length, biologically active multi-pass TPs is challenging due to their complex, hydrophobic nature.
ACROBiosystems has developed specialized platforms to produce highly active, full-length multi-pass TPs, including CD20, Claudin18.2, CD133, GPRC5D, CXCR4, CCR5, and CCR8. These proteins support drug development, antibody characterization, and mechanistic studies, driving next-generation therapeutic advancements. Read more
Technology Platforms and Related Products
VLP Platform
By incorporating viral envelope and capsid proteins, this system transforms cell membranes into soluble lipid bilayer particles enriched with properly folded, full-length multi-pass TPs.
- Full-length TPs
- Higher abundance than that of overexpressing cells
- Higher immunogenicity
- Best targets for dendritic cells and phage display (100-300nm)
- Suitable for immunization /ELISA /SPR/BLI /cell experiment /CAR detection
Detergent Micelle Platform
- TPs with complete conformation
- Can be accurately quantified
- Suitable for immunization /ELISA /SPR/BLI
Nanodisc Platform
By removing detergents, Nanodisc-based TPs offer improved compatibility for applications such as CAR expression tests.ACROBiosystems has continuously optimized the Nanodisc assembly process to support industrial-scale production
- Full-length TPs are in a natural membrane environment retaining high biological activity
- High hydrophilicity without detergents
- Suitable for immunization /ELISA /SPR/BLI /cell experiment /CAR detection
