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Focus Biomolecules - Exclusive and Popular Small Molecules

Innovative Cellular Signaling Tools: Inhibitors, Agonists and Other Modulators

Focus Biomolecules provides high-quality small molecule research tools for studying cellular signaling pathways, including inhibitors, agonists and specialized modulators. The portfolio supports cancer, stem cell, epigenetics, GPCR, immunology, neurodegeneration and metabolism research, with exclusive first-to-market compounds alongside popular reference molecules for reproducible in vitro and in vivo studies.

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Premium Quality: Focus Biomolecules is renowned for its stringent quality standards, ensuring the purity and consistency of every product.
Comprehensive Portfolio: Explore a vast range of small molecules for applications in cell signaling, epigenetics, cancer research, and more.
Scientifically Backed: Products are developed with deep scientific expertise to support cutting-edge research.

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New Molecules

PBA | TRPM4 channel blocker

Cat# 10-4470

CAS: 3128041-29-9

PBA (3128041-29-9) is a potent and selective TRPM4 channel blocker (IC₅₀(HCT116) = 0.15 µM; IC₅₀(HEK293) = 0.34 µM). Active in both human and mouse. TRPM4 blockers are of interest in treating cardiovascular diseases, neuronal diseases, and cancer. More

GCN2iB | GCN2 inhibitor

Cat# 10-4332

CAS: 2183470-12-2

GCN2iB (2183470-12-2) is a potent (IC₅₀ = 2.4 nM) and highly selective (against 468 kinases) inhibitor of general control nonderepressible 2 (GCN2), an important kinase involved in amino acid homeostasis. More

T863 | DGAT1 inhibitor

Cat# 10-4460

CAS: 701232-20-4

T863 (701232-20-4) is a potent (IC₅₀ = 49 nM CPM fluorescent assay; 17 nM TLC assay) and selective (against DGAT2 and MGATs 2 and 3) inhibitor of diacylglycerol transferase 1 (DGAT1). In mice, it caused weight loss, increased insulin sensitivity, alleviated hepatic steatosis, and reduced triglyceride and cholesterol levels. More

First-to-Market Exclusive Signaling Molecules

Gliocidin | Nicotinamide-mimetic prodrug

Cat# 10-3952

CAS: 62289-81-0

Gliocidin (62289-81-0) is a nicotinamide-mimetic prodrug targeting purine biosynthesis in glioblastoma (IC50 = 150 nM). It converts via the NAD+ salvage pathway to gliocidin-adenine dinucleotide, inhibiting IMPDH2, leading to guanylate depletion and cell death. Gliocidin crosses the blood-brain barrier, suppresses glioblastoma in mice, shows synergy with temozolomide, and inhibits SARS 3CLPRO protease. More

CDD-2789 | ALK1/2 inhibitor

Cat# 10-4451

CAS: 3052084-77-9

CDD-2789 (3052084-77-9) is a potent (IC₅₀ = 3.9 nM ALK1; 2.1 nM ALK2) and selective ALK1/2 inhibitor. It attenuated activin A and BMP-induced phosphorylated SMAD1/5 activation in fibroblasts in a dose-dependent manner. More

WX-02-37 | SARM1 inhibitor

Cat# 10-3968

CAS: 3020765-61-8

WX-02-37 (3020765-61-8) is an allosteric, covalent SARM1 inhibitor (IC₅₀ = 1.5 µM). It inhibited SARM1-dependent cADPR production in the human cell lines SH-SY5Y and 22Rv1. WX-02-37 protected mice from vacor- and vincristine-induced neurite degeneration. More

WX-02-23 | Spliceosome/FOXA1 modulator

Cat# 10-3969

CAS: 2929223-35-6

WX-02-23 (2929223-35-6) is a spliceosome modulator that binds SF3B1, enhancing DDX42 interaction. It shows anti-proliferative effects in Panc 05.04 and Panc 04.03 cells and covalently binds FOXA1 at Cysteine 258 (EC50 = 2 µM). WX-02-23 alters FOXA1 activity by relaxing its DNA-binding motif, impacting chromatin accessibility. More

TLX agonist 31 | TLX agonist

Cat# 10-3945

CAS: 3055146-41-0

TLX agonist 31 (3055146-41-0) is a ligand (EC₅₀ = 100 nM; Kd = 160 nM)) for the human tailless homologue receptor (TLX), a transcription factor that acts as a master regulator of neural stem cell homeostasis. A potential new target for treating neurological pathologies. More

EV-96 | Cysteine-reactive T cell activation suppressor

Cat# 10-3949

CAS: N/A

EV-96 is a cysteine-reactive immunosuppressive agent that suppresses T cell activation (EC₅₀ <2.5 µM) via inhibition of NF-kB activation and degradation of key immune-relevant proteins including ITK, TEC, and CYTIP. EV-96 suppresses T cell activation by inhibiting the splicing factor SF3B1. More

STING Degrader 2 | STING molecular glue

Cat# 10-3939

CAS: N/A

STING Degrader 2 is a molecular glue that covalently binds both STING and RNF126 E3 ligase leading to proteasomal degradation. It displayed sustained STING degradation with faster onset and at lower concentration (3 µM) when compared to the STING PROTAC SP23. More

Popular Molecules

Resiniferatoxin | TRPV1 activator

Cat# 10-2103

CAS: 57444-62-9

Resiniferatoxin (57444-62-9) is an ultrapotent TRPV1 activator (Ki=43 pM). Resiniferatoxin is 100-10,000 fold more potent than capsaicin for most responses yet displays a spectrum of activity distinct from capsaicin. A potent sensory neuron excitotoxin. Induces a long lasting analgesia in a rodent model of burn pain. More

YM-254890 | Gαq inhibitor

Cat# 10-1590

CAS: 568580-02-9

YM-254890 (568580-02-9) is a novel Gα_q/11 inhibitor. U46619-induced platelet aggregation is inhibited but phorbol ester- or ionophore-induced aggregation is not (IC₅₀ = 0.1-0.2 μM). It blocks Pasteurella multocida toxin-mediated activation of Gα_q. A highly useful new tool for studying Gα_q/11-coupled receptor signaling and resulting cellular events. More

7-Cl-O-Nec1 | RIP1 inhibitor

Cat# 10-4544

CAS: 852391-15-2

7-Cl-O-Nec1 (852391-15-2) is a potent, selective, and metabolically stable RIP1 inhibitor (IC50 = 206 nM) with no off-target IDO inhibition. It outperforms Necrostatin-1 in blocking necroptosis in Jurkat cells (EC50 = 210 nM) and shows no cytotoxicity at high concentrations (100 µM). With favorable pharmacokinetics in mice, 7-Cl-O-Nec1 is preferred for cellular and in vivo studies. More

Look to Focus for cutting-edge Cell Signaling reagents

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