Focus Biomolecules - Exclusive and Popular Small Molecules

Innovative Cellular Signaling Tools: Inhibitors, Agonists and Other Modulators

Focus Biomolecules brings innovative cellular signaling tools to the life sciences research community by providing a comprehensive selection of small molecule research tools (inhibitors and other modulators) of the highest quality, backed by superior customer and technical support.

Stay at the forefront of discovery with Focus Biomolecules‘ ever-expanding portfolio of cutting-edge biochemicals for cell signaling research. Fuel your progress with new products added weekly. 

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Popular Cell Signaling Modulators

CHIR-99021 | GSK3ß inhibitor

Cat# 10-1279

CAS: 252917-06-9

CHIR-99021 | GSK3ß inhibitor

CHIR-99021 is a potent and selective inhibitor of glycogen synthase kinase-3β (GSK3β, IC50 = 5 nM) and GSK3α (IC50 = 10 nM). Induces osteoblastogenesis, increases mineralization and inhibits adipogenesis in ST2 cells. Promotes replication and survival of pancreatic beta cells. Cell permeable and active in vivo. Read more

IBMX | PDE inhibitor

Cat# 10-1008

CAS: 28822-58-4

IBMX | PDE inhibitor

IBMX is a pan-specific inhibitor of phosphodiesterases (IC50=2-50 µM). Inhibition of PDEs leads to increased concentration of intracellular cAMP which activates PKA. IBMX does not inhibit PDE8 or PDE9. Weak adenosine receptor antagonist. Read more

Mitoquinone | Mitochondria-targeted antioxidant

Cat# 10-1363

CAS: 444890-41-9

Mitoquinone | Mitochondria-targeted antioxidant

Mitoquinone (444890-40-9) is a mitochondria-targeted antioxidant. Displays cardio- and neuroprotective effects.1 Displays beneficial effects in mouse models of Alzheimer’s disease.2 Mitoquinone protects pancreatic β-cells against oxidative stress and improves insulin secretion.3 Cell permeable. Read more

Cat. No.
10-1008 IBMX PDE inhibitor (pan-spec)
10-1191 Thiazovivin Induces stem cell generation
10-1279 CHIR-99021 GSK3β inhibitor
10-1314 Lactacystin Proteasome inhibitor
10-1327 A83-01 ALK inhibitor
10-1338 Apomorphine HCl Dopamine agonist
10-1346 Leupeptin hemisulfate Trypsin-like cysteine protease inhibitor
Cat. No.
10-1363 Mitoquinone Mitochondria-targeted antioxidant
10-1590 YM-254890 Gq inhibitor
10-1614 Herboxidiene Spliceosome inhibitor
10-2299 DMPO Spin trap
10-2301 Y-27632 dihydrochloride ROCK family kinase inhibitor
10-3326 Koningic acid Glyceraldehyde-3-phosphate dehydrogenase inhibitor
10-5400 Biotin-isoxazole Precipitates RNA Binding Proteins

Exclusive / Semi-Exclusive Cell Signaling Modulators

P053 | Protein phosphatase 5 inhibitor

Cat# 10-4060

CAS: 1022417-69-1

P053_Protein phosphatase 5 inhibitor

P053 is a selective inhibitor of protein phosphatase 5 (PP5) – IC50 = 706 nM.  PP5 regulates signaling cascades that are responsible for tumor initiation, progression, and metastasis and is thus an interesting anticancer target.  P053 induced apoptosis in 786-O renal carcinoma cells.  Inhibition of PP5 by P053 prevents deactivation of the death effector protein FADD and activates the extrinsic apoptosis pathway complex II. Read more

DRP1 inhibitor 4a | Mitochondrial fission inhibitor

Cat# 10-3912


DRP1 inhibitor 4a_Mitochondrial fission inhibitor

DRP1 inhibitor 4a blocks (IC50 = 100 nM) the protein-protein interaction between dynamin related protein 1 (DRP1) and the mitochondrial membrane receptor MiD49 preventing mitochondrial fragmentation.1  It prevented roughly half of mitochondrial fragmentation in A549 cells caused by carbonylcyanide-3-chlorophenylhydrazone (CCCP). Read more

YL-365 | GPR34 antagonist

Cat# 10-3988


YL-365_GPR34 antagonist

YL-365 is a potent (IC50 = 17 nM) and selective antagonist of GPR34, a GPCR for lysophosphatidylserine.1 GPR34 is highly expressed in various immune cells and has been implicated in several types of cancer.2  YL-365 showed no activity against various other GPCRs as well as a panel of 378 kinases.  It alleviated hyperalgesia in a mouse model of neuropathic pain via downregulation of iNOS in M1 microglia without any toxicity. Read more

UCB9608 | Highly selective PI4KIIIß inhibitor

Cat# 10-4857

CAS: 1616413-96-7

UCB9608_PI4KIIIß inhibitor
UCB9608_PI4KIIIß inhibitor

UCB9608 (1616413-96-7) is a potent (IC50 = 5 nM), highly selective, and orally bioavailable inhibitor of the phosphatidylinositol kinase PI4KIIIß. It acts as a potent immunosuppressive agent and was able to significantly prolong heterotopic allograft retention in a mouse model. UCB9608 preserved graft tolerance in mice.  Read more

Cat. No.
10-1324 17-GMP-APA-GA Geldanamycin with ADC linker
10-1413 PBMC TRPM8 blocker
10-1431 CCG-4986 RGS4 inhibitor
10-1433 Bromo-PTC Cruzain inhibitor
10-1497 AI-3 ARE activator
10-1502 GPI-16552 PARG inhibitor
10-1562 NSC-47924 PHLP phosphatase inhibitor / Laminin inhibitor
10-1564 EPAC 5376753 EPAC inhibitor
10-1567 Compound 115-7c HSP70 modulator
10-1577 17-AHA-geldanamycin Geldanamycin affinity chromatography ligand
10-1580 Mito-Photo-DNP Mitochondria specific, photo-activated protonophore
10-1601 17-PAAG Propargyl-geldanamycin click reagent
10-1606 SMED-1 Dexamethasone sensitizer
10-1608 Seriniquinone Autophagy inducer
10-1621 Dienamide A2 Novel cannabinoid CB2 agonist; antiinflammatory
10-2103 Resiniferatoxin TRPV1 agonist
10-2746 Cereulide Mitochondrial toxin
10-3125 Dihydroouabain Endogenous ouabain-like factor
10-3208 Safracin B Anticancer agent
10-3243 Ilicicolin H Cytochrome bc1 reductase inhibitor
10-3497 WP631 Inhibits SP-1 activated transcription
10-3538 Tomentosin NFkB activation inhibitor
10-3701 Ranolazine Selective sodium channel blocker
10-3712 DO264 ABHD12 inhibitor
10-3756 NOTUMib-1 NOTUM inhibitor, restores Wnt signaling
10-3909 TH301 Selective circadian clock protein CRY2 stabilizer
10-3911 KL044 Cryptochrome stabilizer
10-3912 DRP1 inhibitor 4a Mitochondrial fission inhibitor
10-3915 Mitoquinone mesylate (25 wt%) / b-cyclodextrin complex Mitochondria-targeted antioxidant
10-3916 AP39 Mitochondria-targeted hydrogen sulfide donor
10-3918 IMT1 Mitochondrial DNA transcription inhibitor/RNA Polymerase inhibitor
10-3919 IMT1B Mitochondrial DNA transcription inhibitor/RNA Polymerase inhibitor
10-3923 CIB-3b Inhibitor of microRNA biogenesis
10-3924 PY-60 YAP Activator
10-3948 SLU-PP-332 pan-ERR agonist/Exercise mimetic
10-3950 IMP-1700 Bacterial DNA repair inhibitor
10-3951 MAC-545496 GraR inhibitor
10-3961 ML300 SARS-CoV 3CL protease inhibitor
Cat. No.
10-3977 C19-9 non-RGD integrin αvß3 receptor inhibitor
10-3980 BAY-1797 P2X4 antagonist
10-3988 YL-365 GPR34 antagonist
10-4037 BZ1 BPTF inhibitor
10-4038 iBAP-II BAP1 deubiquitinase inhibitor
10-4041 TETi76 ester TET inhibitor
10-4060 P053 Protein phosphatase 5 inhibitor
10-4075 SIC5-6 Separase inhibitor
10-4080 UNC7467 IP6K inhibitor
10-4086 Serodolin ß-Arrestin-biased 5-HT7 antagonist
10-4096 VY-3-135 Acetyl-CoA synthetase 2 inhibitor
10-4145 2E151 Vaccine co-adjuvant
10-4148 S07-2010 pan-AKR1C inhibitor
10-4188 DS18561882 MTHFD2 inhibitor
10-4395 SLF1081851 Sphingosine-1-phosphate transporter inhibitor
10-4396 SLB1122168 Spns2 inhibitor
10-4516 GW1100 GPR40 antagonist
10-4560 CT-2584 CTP: choline-phosphate cytidylyltransferase inhibitor
10-4577 FSG67 GPAT inhibitor
10-4624 TH1760 NUDT15 inhibitor
10-4626 NG-497 Human ATGL inhibitor
10-4655 AE 51310 OPN4/Melanopsin antagonist
10-4662 VU0810464 Kir3 activator
10-4691 JH-X-119-01 Selective IRAK1 inhibitor
10-4700 SU0268 OGG1 inhibitor
10-4747 iGP-1 Mitochondrial GPDH inhibitor
10-4756 Deucravacitinib Allosteric TYK2 inhibitor
10-4849 UZH2 METTL3 inhibitor
10-4857 UCB9608 Highly selective PI4KIIIß inhibitor
10-4892 Methylbenzoprim Dual TYMS/DHFR inhibitor
10-4963 GRL-0667 Noncovalent inhibitor of SARS-CoV PLpro
10-4966 Jun9-72-2 SARS-CoV-2 papain-like protease (PLpro) inhibitor
10-4981 OTUDin3 OTUD3 inhibitor
10-4990 Z-Leu-Leu-Leu-vinylsulfone Proteasome inhibitor
10-4992 AOH1996 PCNA inhibitor
10-5103 AS-1949490 SHIP2 inhibitor
10-5161 DBIC DNMT3B S-nitrosylation inhibitor
10-5162 DBIC-neg2 Negative control for DBIC
10-5373 PSB-1584 GPR84 Agonist
10-5492 Mito-lonidamine Mitochondria-targeted antiglycolytic agent
10-5556 PNF1 Angiogenesis inducer
10-5723 AqB013 Aquaporin blocker