Focus Biomolecules - Exclusive and Popular Small Molecules

Innovative Cellular Signaling Tools: Inhibitors, Agonists and Other Modulators

Focus Biomolecules brings innovative cellular signaling tools to the life sciences research community by providing a comprehensive selection of small molecule research tools (inhibitors and other modulators) of the highest quality, backed by superior customer and technical support.

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Premium Quality: Focus Biomolecules is renowned for its stringent quality standards, ensuring the purity and consistency of every product.
Comprehensive Portfolio: Explore a vast range of small molecules for applications in cell signaling, epigenetics, cancer research, and more.
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First-to-Market Exclusive Signaling Molecules

Gliocidin | Nicotinamide-mimetic prodrug

Cat# 10-3952

CAS: 62289-81-0

Gliocidin (62289-81-0) is a nicotinamide-mimetic prodrug targeting purine biosynthesis in glioblastoma (IC50 = 150 nM). It converts via the NAD+ salvage pathway to gliocidin-adenine dinucleotide, inhibiting IMPDH2, leading to guanylate depletion and cell death. Gliocidin crosses the blood-brain barrier, suppresses glioblastoma in mice, shows synergy with temozolomide, and inhibits SARS 3CLPRO protease. More

CDD-2789 | ALK1/2 inhibitor

Cat# 10-4451

CAS: 3052084-77-9

CDD-2789 (3052084-77-9) is a potent (IC₅₀ = 3.9 nM ALK1; 2.1 nM ALK2) and selective ALK1/2 inhibitor. It attenuated activin A and BMP-induced phosphorylated SMAD1/5 activation in fibroblasts in a dose-dependent manner. More

WX-02-37 | SARM1 inhibitor

Cat# 10-3968

CAS: 3020765-61-8

WX-02-37 (3020765-61-8) is an allosteric, covalent SARM1 inhibitor (IC₅₀ = 1.5 µM). It inhibited SARM1-dependent cADPR production in the human cell lines SH-SY5Y and 22Rv1. WX-02-37 protected mice from vacor- and vincristine-induced neurite degeneration. More

WX-02-23 | Spliceosome/FOXA1 modulator

Cat# 10-3969

CAS: 2929223-35-6

WX-02-23 (2929223-35-6) is a spliceosome modulator that binds SF3B1, enhancing DDX42 interaction. It shows anti-proliferative effects in Panc 05.04 and Panc 04.03 cells and covalently binds FOXA1 at Cysteine 258 (EC50 = 2 µM). WX-02-23 alters FOXA1 activity by relaxing its DNA-binding motif, impacting chromatin accessibility. More

TLX agonist 31 | TLX agonist

Cat# 10-3945

CAS: 3055146-41-0

TLX agonist 31 (3055146-41-0) is a ligand (EC₅₀ = 100 nM; Kd = 160 nM)) for the human tailless homologue receptor (TLX), a transcription factor that acts as a master regulator of neural stem cell homeostasis. A potential new target for treating neurological pathologies. More

EV-96 | Cysteine-reactive T cell activation suppressor

Cat# 10-3949

CAS: N/A

EV-96 is a cysteine-reactive immunosuppressive agent that suppresses T cell activation (EC₅₀ <2.5 µM) via inhibition of NF-kB activation and degradation of key immune-relevant proteins including ITK, TEC, and CYTIP. EV-96 suppresses T cell activation by inhibiting the splicing factor SF3B1. More

STING Degrader 2 | STING molecular glue

Cat# 10-3939

CAS: N/A

STING Degrader 2 is a molecular glue that covalently binds both STING and RNF126 E3 ligase leading to proteasomal degradation. It displayed sustained STING degradation with faster onset and at lower concentration (3 µM) when compared to the STING PROTAC SP23. More

Popular Molecules

Resiniferatoxin | TRPV1 activator

Cat# 10-2103

CAS: 57444-62-9

Resiniferatoxin (57444-62-9) is an ultrapotent TRPV1 activator (Ki=43 pM). Resiniferatoxin is 100-10,000 fold more potent than capsaicin for most responses yet displays a spectrum of activity distinct from capsaicin. A potent sensory neuron excitotoxin. Induces a long lasting analgesia in a rodent model of burn pain. More

YM-254890 | Gαq inhibitor

Cat# 10-1590

CAS: 568580-02-9

YM-254890 (568580-02-9) is a novel Gα_q/11 inhibitor. U46619-induced platelet aggregation is inhibited but phorbol ester- or ionophore-induced aggregation is not (IC₅₀ = 0.1-0.2 μM). It blocks Pasteurella multocida toxin-mediated activation of Gα_q. A highly useful new tool for studying Gα_q/11-coupled receptor signaling and resulting cellular events. More

7-Cl-O-Nec1 | RIP1 inhibitor

Cat# 10-4544

CAS: 852391-15-2

7-Cl-O-Nec1 (852391-15-2) is a potent, selective, and metabolically stable RIP1 inhibitor (IC50 = 206 nM) with no off-target IDO inhibition. It outperforms Necrostatin-1 in blocking necroptosis in Jurkat cells (EC50 = 210 nM) and shows no cytotoxicity at high concentrations (100 µM). With favorable pharmacokinetics in mice, 7-Cl-O-Nec1 is preferred for cellular and in vivo studies. More

New Molecules

FB23-2 | FTO inhibitor

Cat# 10-4852

CAS: 2243736-45-8

FB23-2 (2243736-45-8) is an FTO inhibitor (IC50 = 2.6 µM) with selective anti-proliferative activity in NB4 (IC50 = 0.8 µM) and MONOMAC6 (IC50 = 1.5 µM) cells. It induces myeloid differentiation, apoptosis in AML cells, and suppresses hepatocellular carcinoma cell proliferation and migration by downregulating ERBB3 and TUBB4A expression. More

SCR7 pyrazine | CRISPR enhancer

Cat# 10-3652

CAS: 14892-97-8

SCR7 pyrazine (14892-97-8) enhances CRISPR/Cas9 precision up to 19-fold by inhibiting nonhomologous end joining (NHEJ). It targets DNA ligases I and III over ligase IV, induces cancer cell death, and boosts double-strand break therapies. It also enables site-specific methylation for sustained gene silencing in vitro and in vivo. More

GW3965 HCl | LXR agonist

Cat# 10-3069

CAS: 405911-17-3

GW3965 (405911-17-3) is a potent and selective LXR agonist, activating human LXRα and β in cell-based reporter gene assays (EC₅₀=190 and 30 nM respectively). Since LXR is a master regulator of cholesterol and fatty acid metabolism, GW3965 exerts a variety of effects including antiatherosclerotic, antiinflammatory as well as antinociceptive and alteration of fat tissue distribution. Orally active. More

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