Focus Biomolecules - Exclusive and Popular Small Molecules

Innovative Cellular Signaling Tools: Inhibitors, Agonists and Other Modulators

Focus Biomolecules brings innovative cellular signaling tools to the life sciences research community by providing a comprehensive selection of small molecule research tools (inhibitors and other modulators) of the highest quality, backed by superior customer and technical support.

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Physiological Processes & Diseases

Biochemical Targets

Popular Cell Signaling Modulators

CHIR-99021 | GSK3ß inhibitor

Cat# 10-1279

CAS: 252917-06-9

CHIR-99021 is a potent and selective inhibitor of glycogen synthase kinase-3β (GSK3β, IC₅₀ = 5 nM) and GSK3α (IC₅₀ = 10 nM). Induces osteoblastogenesis, increases mineralization and inhibits adipogenesis in ST2 cells. Promotes replication and survival of pancreatic beta cells. Cell permeable and active in vivo. Read more

IBMX | PDE inhibitor

Cat# 10-1008

CAS: 28822-58-4

IBMX is a pan-specific inhibitor of phosphodiesterases (IC₅₀=2-50 µM). Inhibition of PDEs leads to increased concentration of intracellular cAMP which activates PKA. IBMX does not inhibit PDE8 or PDE9. Weak adenosine receptor antagonist. Read more

Mitoquinone | Mitochondria-targeted antioxidant

Cat# 10-1363

CAS: 444890-41-9

Mitoquinone (444890-40-9) is a mitochondria-targeted antioxidant. Displays cardio- and neuroprotective effects.¹ Displays beneficial effects in mouse models of Alzheimer’s disease.² Mitoquinone protects pancreatic β-cells against oxidative stress and improves insulin secretion.³ Cell permeable. Read more

Cat. No.	Product	Description
10-1008	IBMX	PDE inhibitor (pan-spec)
10-1191	Thiazovivin	Induces stem cell generation
10-1279	CHIR-99021	GSK3β inhibitor
10-1314	Lactacystin	Proteasome inhibitor
10-1327	A83-01	ALK inhibitor
10-1338	Apomorphine HCl	Dopamine agonist
10-1346	Leupeptin hemisulfate	Trypsin-like cysteine protease inhibitor

Cat. No.	Product	Description
10-1363	Mitoquinone	Mitochondria-targeted antioxidant
10-1590	YM-254890	Gq inhibitor
10-1614	Herboxidiene	Spliceosome inhibitor
10-2299	DMPO	Spin trap
10-2301	Y-27632 dihydrochloride	ROCK family kinase inhibitor
10-3326	Koningic acid	Glyceraldehyde-3-phosphate dehydrogenase inhibitor
10-5400	Biotin-isoxazole	Precipitates RNA Binding Proteins

Exclusive / Semi-Exclusive Cell Signaling Modulators

P053 | Protein phosphatase 5 inhibitor

Cat# 10-4060

CAS: 1022417-69-1

P053 is a selective inhibitor of protein phosphatase 5 (PP5) – IC₅₀ = 706 nM. PP5 regulates signaling cascades that are responsible for tumor initiation, progression, and metastasis and is thus an interesting anticancer target. P053 induced apoptosis in 786-O renal carcinoma cells. Inhibition of PP5 by P053 prevents deactivation of the death effector protein FADD and activates the extrinsic apoptosis pathway complex II. Read more

DRP1 inhibitor 4a | Mitochondrial fission inhibitor

Cat# 10-3912

CAS: N/A

DRP1 inhibitor 4a blocks (IC₅₀ = 100 nM) the protein-protein interaction between dynamin related protein 1 (DRP1) and the mitochondrial membrane receptor MiD49 preventing mitochondrial fragmentation.¹ It prevented roughly half of mitochondrial fragmentation in A549 cells caused by carbonylcyanide-3-chlorophenylhydrazone (CCCP). Read more

YL-365 | GPR34 antagonist

Cat# 10-3988

CAS: N/A

YL-365 is a potent (IC₅₀ = 17 nM) and selective antagonist of GPR34, a GPCR for lysophosphatidylserine.¹ GPR34 is highly expressed in various immune cells and has been implicated in several types of cancer.² YL-365 showed no activity against various other GPCRs as well as a panel of 378 kinases. It alleviated hyperalgesia in a mouse model of neuropathic pain via downregulation of iNOS in M1 microglia without any toxicity. Read more

UCB9608 | Highly selective PI4KIIIß inhibitor

Cat# 10-4857

CAS: 1616413-96-7

UCB9608 (1616413-96-7) is a potent (IC₅₀ = 5 nM), highly selective, and orally bioavailable inhibitor of the phosphatidylinositol kinase PI4KIIIß. It acts as a potent immunosuppressive agent and was able to significantly prolong heterotopic allograft retention in a mouse model. UCB9608 preserved graft tolerance in mice. Read more

Cat. No.	Product	Description
10-1324	17-GMP-APA-GA	Geldanamycin with ADC linker
10-1413	PBMC	TRPM8 blocker
10-1431	CCG-4986	RGS4 inhibitor
10-1433	Bromo-PTC	Cruzain inhibitor
10-1497	AI-3	ARE activator
10-1502	GPI-16552	PARG inhibitor
10-1562	NSC-47924	PHLP phosphatase inhibitor / Laminin inhibitor
10-1564	EPAC 5376753	EPAC inhibitor
10-1567	Compound 115-7c	HSP70 modulator
10-1577	17-AHA-geldanamycin	Geldanamycin affinity chromatography ligand
10-1580	Mito-Photo-DNP	Mitochondria specific, photo-activated protonophore
10-1601	17-PAAG	Propargyl-geldanamycin click reagent
10-1606	SMED-1	Dexamethasone sensitizer
10-1608	Seriniquinone	Autophagy inducer
10-1621	Dienamide A2	Novel cannabinoid CB2 agonist; antiinflammatory
10-2103	Resiniferatoxin	TRPV1 agonist
10-2746	Cereulide	Mitochondrial toxin
10-3125	Dihydroouabain	Endogenous ouabain-like factor
10-3208	Safracin B	Anticancer agent
10-3243	Ilicicolin H	Cytochrome bc1 reductase inhibitor
10-3497	WP631	Inhibits SP-1 activated transcription
10-3538	Tomentosin	NFkB activation inhibitor
10-3701	Ranolazine	Selective sodium channel blocker
10-3712	DO264	ABHD12 inhibitor
10-3756	NOTUMib-1	NOTUM inhibitor, restores Wnt signaling
10-3909	TH301	Selective circadian clock protein CRY2 stabilizer
10-3911	KL044	Cryptochrome stabilizer
10-3912	DRP1 inhibitor 4a	Mitochondrial fission inhibitor
10-3915	Mitoquinone mesylate (25 wt%) / b-cyclodextrin complex	Mitochondria-targeted antioxidant
10-3916	AP39	Mitochondria-targeted hydrogen sulfide donor
10-3918	IMT1	Mitochondrial DNA transcription inhibitor/RNA Polymerase inhibitor
10-3919	IMT1B	Mitochondrial DNA transcription inhibitor/RNA Polymerase inhibitor
10-3923	CIB-3b	Inhibitor of microRNA biogenesis
10-3924	PY-60	YAP Activator
10-3948	SLU-PP-332	pan-ERR agonist/Exercise mimetic
10-3950	IMP-1700	Bacterial DNA repair inhibitor
10-3951	MAC-545496	GraR inhibitor
10-3961	ML300	SARS-CoV 3CL protease inhibitor

Cat. No.	Product	Description
10-3977	C19-9	non-RGD integrin αvß3 receptor inhibitor
10-3980	BAY-1797	P2X4 antagonist
10-3988	YL-365	GPR34 antagonist
10-4037	BZ1	BPTF inhibitor
10-4038	iBAP-II	BAP1 deubiquitinase inhibitor
10-4041	TETi76 ester	TET inhibitor
10-4060	P053	Protein phosphatase 5 inhibitor
10-4075	SIC5-6	Separase inhibitor
10-4080	UNC7467	IP6K inhibitor
10-4086	Serodolin	ß-Arrestin-biased 5-HT7 antagonist
10-4096	VY-3-135	Acetyl-CoA synthetase 2 inhibitor
10-4145	2E151	Vaccine co-adjuvant
10-4148	S07-2010	pan-AKR1C inhibitor
10-4188	DS18561882	MTHFD2 inhibitor
10-4395	SLF1081851	Sphingosine-1-phosphate transporter inhibitor
10-4396	SLB1122168	Spns2 inhibitor
10-4516	GW1100	GPR40 antagonist
10-4560	CT-2584	CTP: choline-phosphate cytidylyltransferase inhibitor
10-4577	FSG67	GPAT inhibitor
10-4624	TH1760	NUDT15 inhibitor
10-4626	NG-497	Human ATGL inhibitor
10-4655	AE 51310	OPN4/Melanopsin antagonist
10-4662	VU0810464	Kir3 activator
10-4691	JH-X-119-01	Selective IRAK1 inhibitor
10-4700	SU0268	OGG1 inhibitor
10-4747	iGP-1	Mitochondrial GPDH inhibitor
10-4756	Deucravacitinib	Allosteric TYK2 inhibitor
10-4849	UZH2	METTL3 inhibitor
10-4857	UCB9608	Highly selective PI4KIIIß inhibitor
10-4892	Methylbenzoprim	Dual TYMS/DHFR inhibitor
10-4963	GRL-0667	Noncovalent inhibitor of SARS-CoV PLpro
10-4966	Jun9-72-2	SARS-CoV-2 papain-like protease (PLpro) inhibitor
10-4981	OTUDin3	OTUD3 inhibitor
10-4990	Z-Leu-Leu-Leu-vinylsulfone	Proteasome inhibitor
10-4992	AOH1996	PCNA inhibitor
10-5103	AS-1949490	SHIP2 inhibitor
10-5161	DBIC	DNMT3B S-nitrosylation inhibitor
10-5162	DBIC-neg2	Negative control for DBIC
10-5373	PSB-1584	GPR84 Agonist
10-5492	Mito-lonidamine	Mitochondria-targeted antiglycolytic agent
10-5556	PNF1	Angiogenesis inducer
10-5723	AqB013	Aquaporin blocker

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