ichorbio: In vivo Antibodies, Biosimilars, Isotype Controls
Lowest endotoxin level | Highest purity | Best price
ichorbio’s ultra-low endotoxin antibodies have the lowest endotoxin level on the market, significantly reduced aggregation, and the highest purity. The high quality standard positively affects the wellbeing of your animals and minimizes negative effects on cultured cells.
Manufactured in a ISO 9001:2015 and GMP certified facility, you can expect minimal lot to lot variability and improved reproducibility of your experiments.
ichorbio fully focusses on bulk production and offers ultra competitive prices of less than CHF 100.- per 1mg antibody.
Specifications
"Low Endotoxin" and "Ultra-low Endotoxin" Specifications
Low Endotoxin | Ultra-low endotoxin | |
|---|---|---|
Endotoxin level | < 1 EU/mg | < 0.75 EU/mg |
Purity | > 95% | > 98% |
Aggregation | < 5% | < 1% |
Facility | GMP compliant, ISO Quality Standard 9001:2015 | Animal free facility
|
IDEXX IMPACT Test | No | Yes (Impact I) |
Perservative, stabilizer and carrier protein free | Yes | Yes |
Formulated for in vivo use | Yes | Yes |
Product Code | ICHxxxx | ICHxxxxUL |
Animal Welfare at ichorbio - Refinement and Reduction
For ichorbio, the welfare of the animals used for in vivo research is the *key* consideration all researchers should take into consideration before beginning their experiments. Ichorbio’s focus is on creating the highest quality reagents in the industry which will directly impact the quality of the results obtained from them.
- Refinement – thanks to greater antibody efficacy
Incremental improvements to the purity of antibodies over those currently in the market leading to reduced aggregation - Reduction – by reduced numbers of animals used in research
ichorbio antibodies have the lowest endotoxin on the market which positively affects the wellbeing of your animals. Manufacturing in a ISO9001, GMP certified facility ensures minimal lot to lot variability and improved reproducibility.
Biosimilars - Research Grade (RUO)
< 1 EU/mg endotoxin | 1mg – 100mg size | >95% Purity
Biosimilars are biologic medical products that are highly similar to already approved reference products, with no clinically meaningful differences in terms of safety, purity, and efficacy.
IchorBio provides a large range of research grade (RUO) biosimilar antibodies, which are used in various research applications, including immunotherapy and drug development. They offer a range of biosimilars targeting different proteins and receptors, including immune checkpoint inhibitors like PD-1, CTLA-4, and others. These products are often used in preclinical research to study cancer, autoimmune diseases, and other conditions.
Quality and Standards: IchorBio emphasizes the production of biosimilars under stringent quality control to ensure they meet the required standards for research use. They provide detailed product specifications, including purity, endotoxin levels, and bioactivity data.
Bispecific Biosimilars
Conjugated Biosimilars
Antibody Drug Conjugate
Further Biosimilars
In vivo Antibodies
All ICHORBIO primary antibodies are suitable for in vivo use and include CD Marker Antibodies, Mouse Immune Cell Depletion Antibodies, Interferon Antibodies, Cytokine Antibodies, Fc Silenced Antibodies, Immune Checkpoint Antibodies and Isotype Controls
ichorbio vs. Bio X Cell and BioLegend
Low endotoxin formulation
ichorbio Low Endotoxin | Bio X Cell InVivoMAb™ | BioLegend Ultra-LEAF™ | |
|---|---|---|---|
Endotoxin level | < 1 EU/mg | < 2 EU/mg | < 10 EU/mg |
Purity | > 95% | > 95% | ? |
Aggregation | < 5% | n/a | < 3% |
Ultra-low endotoxin formulation
ichorbio Ultra-low Endotoxin | Bio X Cell InVivoPlus™MAb | BioLegend GoInVivo™ | |
|---|---|---|---|
Endotoxin level | < 0.75 EU/mg | < 1 EU/mg | < 1 EU/mg |
Purity | > 98% | > 95% | ? |
Aggregation | < 1% | < 5% | ? |
Isotype Controls - For in vivo use
< 1 EU/mg endotoxin | 1mg – 100mg size | >95% Purity
Isotype controls are an essential component of flow cytometry and other immunoassays, serving as critical negative controls to help discern nonspecific background signals from specific antigen recognition. By matching the primary antibody’s class (isotype) but lacking specificity for the target antigen, isotype controls are pivotal in setting the baseline for experimental interpretation.
ichorbio manufactures a broad range of human, mouse, rat and hamster isotype controls for in vivo use. Ichorbio isotype controls are available in bulk quantities – starting at 5mg and available off the shelf up to 100mg.
ichorbio vs. BioLegend - Price comparison of Isotype Controls
The below data is correct as of July 2024 and refers to standard list prices in Switzerland, not including any special offers.
Human IgG1 κ Isotype Control Antibody
ichorbio Low Endotoxin (<1 EU/mg) | BioLegend Ultra-LEAFTM (<10 EU/mg) | |
|---|---|---|
Quantity | 5mg | 1 mg >> 5mg (calc.) |
Cat# | ICH2254-5MG | 403502 |
CHF (July 24) | 445.- | 495.- >> 2475.- |
Mouse IgM Isotype Control Antibody
ichorbio Low Endotoxin (<1 EU/mg) | BioLegend Ultra-LEAFTM (<10 EU/mg) | |
|---|---|---|
Quantity | 25mg | 25mg |
Cat# | ICH2252-25MG | 401632 |
CHF (July 24) | 1360.- | 1408.- |
Rat IgG2a Isotype Control Antibody
ichorbio Low Endotoxin (<1 EU/mg) | BioLegend Ultra-LEAFTM (<10 EU/mg) | |
|---|---|---|
Quantity | 50mg | 50mg |
Cat# | ICH2244-50MG | 400573 |
CHF (July 24) | 1927.- | 2354.- |
Human IgG2 Isotype Control Antibody
ichorbio Low Endotoxin (<1 EU/mg) | BioLegend Ultra-LEAFTM (<10 EU/mg) | |
|---|---|---|
Quantity | 25mg | 1 mg >> 25mg (calc.) |
Cat# | ICH2255-25MG | 403602 |
CHF (July 24) | 1112.- | 677.->> 16’925.- |
Mouse IgG2b, κ Isotype Control Antibody [MPC-11]
ichorbio Low Endotoxin (<1 EU/mg) | BioLegend Ultra-LEAFTM (<10 EU/mg) | |
|---|---|---|
Quantity | 100mg | 100mg |
Cat# | ICH2250-100MG | 400378 |
CHF (July 24) | 2690.- | 3383.- |
Rat IgG1 Isotype Control Antibody
ichorbio Low Endotoxin (<1 EU/mg) | BioLegend Ultra-LEAFTM (<10 EU/mg) | |
|---|---|---|
Quantity | 100mg | 100mg |
Cat# | ICH2246-100MG | 400462 |
CHF (July 24) | 2690.- | 3383.- |
