-25% on in vivo Antibodies

Code: invivo2026.
Expires 31. Mar 2026. Not summable with other discounts.

-50% on in vivo Buffers

Code: PBSPromo.
Only valid alongside the purchase of  ichorbio in vivo antibodies. Expires 31. Dec 2026. Not summable with other discounts.

ichorbio Promotions

ichorbio_invivo Antibody Promo_Jan26

ichorbio: In vivo Antibodies, Isotype Controls, Biosimilars and Antibody Panels

Lowest endotoxin level | Highest purity | Best price

ichorbio’s ultra-low endotoxin antibodies have the lowest endotoxin level on the market, significantly reduced aggregation, and the highest purity. The high quality standard positively affects the wellbeing of your animals and minimizes negative effects on cultured cells.

Manufactured in a ISO 9001:2015 and GMP certified facility, you can expect minimal lot to lot variability and improved reproducibility of your experiments.

ichorbio fully focusses on bulk production and offers ultra competitive prices of less than CHF 100.- per 1mg antibody.

Featured Product Categories

Specifications: "Low Endotoxin" vs. "Ultra-low Endotoxin"

Improved Animal Welfare - Increased Antibody Efficiency, Reduced Number of Animals

Low Endotoxin
Ultra-low endotoxin
Endotoxin level
< 1 EU/mg
< 0.5 EU/mg
Purity
> 95%
> 98%
Aggregation
< 5%
< 1%
Facility
GMP compliant, ISO 9001:2015
Animal free facility
IDEXX IMPACT Test
No
Yes (Impact I)
Preservatives / carriers
None (protein-free, carrier-free)
None (protein-free, carrier-free)
Formulated for in vivo use
Yes
Yes
Product Code
ICHxxxx
ICHxxxxUL

In vivo Antibodies

Low endotoxin, ultra-low endotoxin and recombinant in vivo antibodies

ichorbio manufactures a broad selection of monoclonal antibodies specifically formulated for in vivo studies, available as low or ultra-low endotoxin and, for many targets, as recombinant antibodies. Antibodies are offered in mg to multi-gram quantities to support everything from pilot experiments to large preclinical studies. Each lot is tested for purity, aggregation and endotoxin, and supplied with technical and safety datasheets.

Key application area

  • Immune cell depletion & modulation: CD4, CD8, CD19, Ly-6G/Ly-6C etc.
  • Immune checkpoint blockade & co-stimulation: PD-1, PD-L1, CTLA-4 etc.
  • Cytokines & receptors: Anti-TNFα, anti-IL-1β, anti-IFNγ, anti-IFNAR1 etc.
  • Mouse immune system targeting antibodies & Fc-silenced variants

Featured in vivo Antibody Targets

3D Rendering of Therapeutic Antibody Binding to PD-1

PD-1

Anti-Mouse:
RMP1-14, RMP1-30, 29F.1A12

PD-L1

Anti-Mouse: 10F.9G2
Anti-Human: 29E.2A3

CD4

Anti-Rat: OX-38
Anti-Mouse: GK1.5, YTS191
Anti-Human: OKT-4

CD29

Anti-Mouse: KMI6

CD28

Anti-Rat: JJ319
Anti-Mouse: 37.51

MHC Class II

Anti-Mouse/Rat: 14-4-4S
Anti-Mouse: Y-3P, M5/114.15.2

CD90

Anti-Mouse: M5/49.4.1, T24/31, HK2.1, OX-7, 30-H12

CD106

Anti-Mouse: M/K-2.7

TNF Alpha

Anti-Mouse: TN3-19.12

Isotype Controls - For in vivo use

Less than 1 EU/mg endotoxin | 1mg - 100mg size | >95% Purity

Isotype controls are an essential component of flow cytometry and other immunoassays. They serve as critical negative controls to distinguish nonspecific background signals from true antigen-specific binding. By matching the primary antibody’s isotype and format while lacking specificity for the target antigen, isotype controls provide the baseline needed for reliable data interpretation and gating. ichorbio manufactures a broad range of isotype controls, produced to the same low-endotoxin, preservative-free standards as their in vivo antibodies.

Highlights

  • Hosts: Human, mouse, rat and hamster 
  • Low endotoxin & extremely low endotoxin levels – all suitable for in vivo administration
  • Different variants and mutations (VHH, LALAPG, Fc plus hinge region etc.)
  • Bulk sizes from 1 mg up to 100 mg off-the-shelf, with larger lots on request

Biosimilars - Research Grade (RUO)

< 1 EU/mg endotoxin | 1mg – 100mg size | >95% Purity

Biosimilars are biologic medical products that are highly similar to already approved reference products, with no clinically meaningful differences in terms of safety, purity, and efficacy.

IchorBio provides a large range of research grade (RUO) biosimilar antibodies, which are used in various research applications, including immunotherapy and drug development. They offer a range of biosimilars targeting different proteins and receptors, including immune checkpoint inhibitors like PD-1, CTLA-4, and others. These products are often used in preclinical research to study cancer, autoimmune diseases, and other conditions.

Quality and Standards: IchorBio emphasizes the production of biosimilars under stringent quality control to ensure they meet the required standards for research use. They provide detailed product specifications, including purity, endotoxin levels, and bioactivity data.

ichorbio Biosimilar Categories

Immune checkpoint inhibitors

ichorbio’s research-grade biosimilars to immune checkpoint inhibitors (e.g. PD-1, PD-L1, CTLA-4 and additional emerging targets) enable you to closely mimic clinically relevant mechanisms of action in a RUO setting. Browse

Bispecific Biosimilars

Bispecific formats bind two different antigens or epitopes simultaneously. Evaluate target engagement, cytotoxicity and signalling in complex in vitro or in vivo systems! Browse

Antibody-drug conjugates (ADCs)

ichorbio research-grade ADC biosimilars support mechanism-of-action studies, resistance profiling and optimisation of target selection and combination partners, without consuming clinical material. Browse

Conjugated Formats

To streamline assay development, many ichorbio biosimilars are also available in directly conjugated versions (fluorophores, biotin or enzyme labels, such as e.g. APC, biotin, DyLight 488, PE, HRP etc. Browse

Featured Biosimilars

Aflibercept, Anti-VEGF Biosimilar

Aflibercept, Anti-VEGF Biosimilar ICH4015

Rituximab, Anti-CD20 Biosimilar

Rituximab, Anti-CD20 Biosimilar ICH4011

Toripalimab, Anti-PD-1 Biosimilars

Toripalimab Western Blot

Nivolumab, Anti-PD-1 Biosimilars

Nivolumab Western Blot

Biosimilar Antibody Panels

Research-grade

ichorbio Immune Checkpoint Panels bundle key in vivo-grade antibodies in one convenient package. Ultra-low endotoxin, high purity and minimal aggregation support cleaner readouts and more reproducible immuno-oncology data.

ichorbio Mouse Biosimilar Antibody Panel

CAR Modulation
Antibody Panel

  • Muromonab Biosimilar
  • Theralizumab Biosimilar
  • Urelumab Biosimilar
  • Pembrolizumab Biosimilar
  • Atezolizumab Biosimilar
  • Fresolimumab Biosimilar

Human Immune CheckPoint
Antibody panel

  • Pembrolizumab Biosimilar
  • Atezolizumab Biosimilar
  • Ipilimumab Biosimilar
  • Tiragolimumab Biosimilar
  • Relatlimab Biosimilar
  • Urelumab Biosimilar
  • Sabatolimab Biosimilar (if selected)
  • Ragifilimab Biosimilar (if selected)

Mouse Immune CheckPoint
Antibody Panel

  • PD-1 (RMP1-14)
  • PD-L1 (10F.9G2)
  • CTLA-4 (9D9)
  • LAG-3 (C9B7W)
  • TIGIT (1G9)
  • TIM-3 (RMT3-23) if selected
  • GITR (DTA-1) if selected

In Vivo Buffers

ichorbio’s in vivo buffer are formulated and tested for in vivo applications. They are low in endotoxin and have been tested in animal models for toxicity. They can be used with all ichorbio in vivo antibodies and biosimilars. Read more

ichorbio In Vivo Buffer Tube