MedChem Express (MCE) Promotion

up to 35% on Screening Libraries

Bioactive Screening Libraries
Diversity Compound Libraries
Custom Compound Libraries

Expires 31st Dec 2024. Not summable with other discounts.

MCE Library Promo24

MedChemExpress (MCE) - Compound Screening Libraries

MCE can provide 200+ compound libraries which include Bioactive Screening Libraries, Diversity Compound Libraries and Virtual Screening Database. These libraries contain over 16 million available compounds. For each compound validated bioactivity data and/or physicochemical properties are available.

The compound libraries are suitable for high-throughput screening (HTS), high-content screening (HCS) and virtual screening (VS).

MCE Compound Library Range

Bioactive Compound Libraries

  • 170+ libraries
  • 1’000+ targets
  • 30’000+ compounds

Fragment Compound Libraries

  • 16’000+ fragments
  • 3D diversity fragment library

Customized Compound Libraries

Select your compound, product form, size, concentration & plate map 

Diversity Compound Libraries

  • 100,000+ compounds
  • 50K Diversity Library
  • 5K Scaffold Library 

High Throughput Screening Libraries

  • 26 Mio.+ compounds and fragments
  • 2 Billion DEL molecules

DNA-Encoded Compound Libraries

  • 68 DEL libraries with billions of DEL molecules

High-Throughput Tool

8-Channel Handheld Screw Cap Decapper

  • Easy operation
  • Dual-use: Capping and decapping
  • Suitable for various types of screw captubes
  • Rechargeable for convenient and quick use

Advantages of MCE Compound library

  • Diverse Product Categories and Quick Updates
  • Rich Experience in Compound Synthesis
  • Strict Quality Management System
  • Rigorous Classification Criteria
  • Full Process Servies

170+ Bioactive Compound Libraries - Ready-to-use

Bioactive Compound Library Parameters

  96-well Format Sample Storage Tube 96-/384- well plate
96-well format 96-384-well format

30 μL, 50 μL, 100 μL
or other size lower than 750 μL

96-well plate: 30 μL, 50 μL, 100 μL or other size lower than 100 μL
384-well plate: 30 μL, 50 μL or other size lower than 50 μL

Sealing Way

Screw Cap

Peelable Foil Seal


10 mM solution for products with stable solution state and solubility no less than 10 mM;
2 mM solution for products with solubility between 2 mM and 10 mM;
3 mg/mL solution for products with unconfirmed molecular weight and solubility no less than 3 mg/mL.


DMSO, Water, Ethanol


-20°C for 1 year; -80°C for 2 years


Product information including targets, bioactivity information, research areas, clinical data, etc.;
Product layout for each plate;
SDF file, contains structure information and requires some specialized software to open (ChemOffice).

Plate Layout 96-well setup 96-384-well setup

Compounds with different concentrations or dissolved in different solutions are put on different plates.
If you have any other requirements for the compounds layout, please let us know before you make the order.


Top Selling Bioactive Screening Libraries

MCE Bioactive Screening Libraries

Bioactive screening libraries are ready-to-use and consist of over 30’000 small molecules with validated biological and pharmacological activities, including natural products, novel compounds, FDA-approved compounds, and compounds in clinical trials.

  • Safety and effectiveness have been confirmed by literatures, patent reports and clinical researches
  • Focuses on hundreds of targets that are key components in the fields of GPCRs, kinases, cancer, epigenetics and stem cell biology, etc.
  • Libraries are updated every week by adding newly published small molecules in the related fields
  • Detailed biological and chemical information on every compound together with the LC/MS and NMR reports
Cat. No. Product Description # Compounds
HY-L001 Bioactive Compound Library Large and comprehensive compound library. 17'068
HY-L001P Bioactive Compound Library Plus Compound library with more novel or rare molecules added. 20'000
HY-L099 Targeted Diversity Library Compounds that have been focused against various biological targets. 2'342
HY-L111 Novel Bioactive Compound Library Compound Library containing a variety of novel bioactive compounds. 1'168

More Top Selling Bioactive Screening Libraries

Drug Repurposing Series FDA-Approved Drug Library Plus
(3,000+ compounds)
All compounds have been completed extensive preclinical and clinical studies and have well-characterized bioactivities, safety and bioavailability properties. Order
Drug Repurposing Compound Library Plus
(4,900+ compounds)
It includes marketed drugs and compounds after clinical phase I, suitable for the study of new drug indications.
Natural Products Series Natural Product Library Plus
(4,500+ compounds)
Compounds in this library have high structural diversity and 3-dimensionality (3D) diversity, with 2,000+ Bemis-Murcko scaffolds. Order
Traditional Chinese Medicine Active Compound Library
(2,700+ compounds)
Compounds are derived from Chinese herbal medicine, including flavonoids, polyphenols, alkaloids, and other structural types. Order
Metabolism Series Human Endogenous Metabolite Compound Library
(1,000+ compounds)
All metabolites come from human tissues and have good biological activity. Order
Metabolism/Protease Compound Library
(3,900+ compounds)
Targets include PDE, Cytochrome P450, DPP4, Proteasome, IDO, MMP, etc. Order
According to Product Features CNS-Penetrant Compound Library
(800+ compounds)
Can pass through the blood-brain barrier ; Tools for developing brain-disease drugs such as brain tumors, mental disorders and neurodegenerative diseases. Order
Covalent Screening Library Plus
(3,000+ compounds)
Small molecules including identified covalent inhibitors and other molecules having common covalent reactive groups as warheads. Order
According to Signaling Pathway or Protein Family Kinase Inhibitor Library
(1,000+ compounds)
The compounds target protein kinase, lipid kinase and carbohydrate kinase (Hexokinase), etc. Order
Epigenetics Compound Library
(1,100+ compounds)
The library contains epigenetics-related compounds targeting HDAC, Histone Demethylase, Histone Acetyltransferase (HAT), DNMT, etc. Order
Disease-Related Compound Libraries Anti-Cancer Compound Library
(6,800+ compounds)
Antitumor compounds, mainly targeting kinases, key proteins in cell cycle regulation, and signaling pathways related to tumor development. Order
Anti-Infection Compound Library
(2,600+ compounds)
Anti-infective compounds with anti-bacterial, anti-virus, anti-fungal and anti-parasite activities. Order
Cell Death Series Ferroptosis Compound Library
(800+ compounds)
Bioactive ferroptosis signal pathway related compounds; targets include iron, dipeptidylpeptidase 4, lipoxygenase, p53, etc. Order
Pyroptosis Compound Library
(1,100+ compounds)
Targets include Caspase-1,
Caspase-4, Caspase-5, gasdermin D, NLRP3, etc. Order

Fragment Compound Libraries

Fragment-based drug discovery (FBDD) is well suited for discovering both drug leads and chemical probes of protein function. It can cover broad areas of chemical space and allows the use of creative chemistry. Fragment-based drug discovery is well-established in industry and has resulted in a variety of drugs entering clinical trials, with two, vemurafenib and venetoclax, already approved.

FBDD also has key attractions for academia. Notably, it is able to engage difficult or novel targets for which no chemical matter may be found in existing HTS collections. FBDD is a powerful method to develop potent small-molecule compounds starting from fragments binding weakly to targets.

FBDD starts by screening libraries of low-molecular weight compounds (fragments) against the target of interest to identify ‘‘hits.’’ The identified hit is then grown into drug-like molecules through different strategies. Although FBDD cannot replace high-throughput screening (HTS) campaigns in drug discovery, it has some attractive advantages such as saving experimental cost, offering diverse hits, and exhibiting multiple ways to develop novel compounds. 

  • 16,000+ fragment compounds for FBDD
  • All compounds follow the Rule of “Three”:
    • molecular weight is ≤300 Da
    • number of H-donors ≤3
    • number of H-acceptors is ≤3
    • cLogP is ≤3
  • Diversified structures, covering a broader chemical space
  • The solubility of most products in DMSO can reach more than 200 mM. Higher concentration is also available.
  • High purity and quality validated by NMR and LC/MS

Customized Compound Libraries

MCE offers customized compound libraries based on your specific needs. You can select your compounds, format (powder/liquid), size and plate map depending on your requirements. Contact us

Customized Compound Library

MCE One-Stop Compound Screening Platform

MedChemExpress compound screening service, combined with bioactive compound libraries, diversity libraries, and fragment libraries, provides a ‘One-Stop Compound Screening Platform’ for customers working on novel drug discovery, novel target discovery, and fundamental research projects.

MedChemExpress one-stop compound screening platform supplies more than 200 screening libraries and a variety of compounds and phenotypic screening services. These services include DNA-encoded compound library screening, virtual screening, high-throughput screening (HTS), ion channel detection, kinase screening & profiling, phenotypic screening, affinity mass spectrometry screening, customized compound synthesis, structural optimization and analysis services, etc.