MedChemExpress (MCE) - Recombinant Proteins (11'000+)
Superior Biological Activity | Low Endotoxin | Attractive Pricing
MCE provides recombinant proteins with various tags, multiple species, superior biological activity and certified low levels of endotoxin.
MCE’s recombinant proteins include: cytokines and growth factors, viral proteins, immune checkpoint proteins, CAR-T related proteins, CD antigens, receptor proteins and enzymes. MCE’s recombinant proteins have been cited in research articles covering many different fields and disciplines, such as cell growth and differentiation, cell signaling, biopharmaceutical target discovery, protein structural and functional analyses, etc.
Advantages of MCE recombinant proteins
- > 11’000 recombinant proteins – Largest portfolio
- Superior Biological Activity – Validated by relevant in vitro or in vivo assays
- Low Endotoxin Levels – Measured by LAL assay
- High Purity – Tested by SDS-PAGE & HPLC
- Excellent Lot-to-Lot Consistency – Confirmed by Lot-to-Lot data
- Competitive Price – High quality with a reasonable price
Cytokines and Growth Factors (2980+)
Cytokines are a large class of low molecular weight proteins, peptides, or glycoproteins that are secreted by various types of immune cells (e.g. macrophages and lymphocytes) as well as endothelial cells. They play an important role in regulating cell growth, differentiation, and activation and are involved in many aspects of the innate and adaptive immune response.
Growth factors are soluble signaling molecules that stimulate various cellular processes during development and tissue healing, including cell proliferation, migration, differentiation, and multicellular morphogenesis.
Human IGF-I (HY-P7018). The purity of human IGF-I is greater than 95% as analyzed by SDS-PAGE under reducing (R) conditions.
Immune Checkpoint Proteins (580+)
The immune checkpoint (ICP) molecules refer to ligand-receptor pairs that exert inhibitory or stimulatory effect on immune responses. Some cancer cells can bind co-inhibitory receptor molecules to limit normal anti-tumor immune responses, thus assisting in immune escape. ICP therapy for cancer encompasses strategies that target regulatory pathways to reinvigorate the anti-tumor function of immune cells. A number of inhibitory immunoreceptors have been identified, including but not limited to PD-1, CTLA-4, LAG3, TIM3, TIGIT and BTLA.
CD Antigens (1960+)
Cluster of differentiation (CD) antigens frequently act as cell-cell or cell-matrix adhesion molecules, cytokine receptors, ionophores, or nutrient transporters. CD antigens are routinely used as cellular markers that can be used to identify and isolate the presence and proportion of specific leukocyte populations and lymphocyte subpopulations.
Fc Receptor Proteins (120+)
Receptors of the fragment crystalizable (Fc) portion of immunoglobulin (Fc receptors, FcRs) are membrane molecules that are expressed on most innate and adaptive immune cells. FcRs belong to the immunoglobulin superfamily and interact with the Fc portion of antibodies to link humoral immune responses to cellular effector mechanisms. Receptors for all classes of immunoglobulins include IgG (FcγRI/CD64, FcγRII/CD32, FcγRIII/CD16, and FcRn), IgE (FCεRI, FcεRII), IgA (FcαRI/CD89), IgM (FcμR), IgD (FcδR) and IgA/IgM (Fcα/μR).-
CAR-T Related Proteins (370+)
Chimeric antigen receptor T (CAR-T) cells, genetically engineered to express synthetic chimeric antigen receptors, can specifically target antigens and kill tumor cells. CAR-T cells can specifically recognize their target antigens through single-stranded fragment variant (scFv) binding domains, leading to T cells in a major histocompatibility complex (MHC)-independent manner activation. Therefore, in CAR design, antigen selection is critical for killing target tumor cells.
