MedChemExpress (MCE) - Recombinant Proteins (14'000+)
Superior Biological Activity | Low Endotoxin | Attractive Pricing
MCE provides recombinant proteins with various tags, multiple species, superior biological activity and certified low levels of endotoxin.
MCE’s recombinant proteins include: cytokines and growth factors, viral proteins, immune checkpoint proteins, CAR-T related proteins, CD antigens, receptor proteins and enzymes. MCE’s recombinant proteins have been cited in research articles covering many different fields and disciplines, such as cell growth and differentiation, cell signaling, biopharmaceutical target discovery, protein structural and functional analyses, etc.
Why Choose MCE Recombinant Proteins?
- > 14’000 recombinant proteins – Largest portfolio
- High Purity – >90% many lot >95% as tested by SDS-PAGE & HPLC
- Excellent Lot-to-Lot Consistency – Confirmed by Lot-to-Lot data
- Superior Biological Activity – Validated by relevant in vitro or in vivo assays
- Low Endotoxin with explicit thresholds – <1.0 EU/µg or <0.1 EU/µg, measured by LAL)
- GMP-Grade recombinant proteins – undergoe rigorous QC testing tests
- 5’500+ products with activity data
- Broad Categories – Cytokines, Growth Factors, , Enzymes, Viral Proteins, etc.
- Vast Range of Species – Human, Mouse, Rat, Monkey, Pig, Rabbit, Virus, etc.
- Scalable Formats – Different pre-packaged sizes. From trial to bulk.
- Competitive Price – High quality with a reasonable price
High Purity
Tested by SDS-PAGE & HPLC
Excellent Lot-to-Lot Consistency
Confirmed lot-to-lot consistency for reproducible results
The ED50 of MedChemExpress (MCE) human VEGF165 from three different lots are similar.
Superior Biological Activity
Validated by relevant in vitro or in vivo assays
Human GM-CSF stimulates cell proliferation of TF-1 cells with an ED50 of less than 0.5 ng/mL.
The ED50 of human VEGF165 from MedChemExpress (MCE)’s each Lot is lower than of Competitor P.
Cytokines and Growth Factors (3390+)
Cytokines are a large class of low molecular weight proteins, peptides, or glycoproteins that are secreted by various types of immune cells (e.g. macrophages and lymphocytes) as well as endothelial cells. They play an important role in regulating cell growth, differentiation, and activation and are involved in many aspects of the innate and adaptive immune response.
Growth factors are soluble signaling molecules that stimulate various cellular processes during development and tissue healing, including cell proliferation, migration, differentiation, and multicellular morphogenesis.
Human IGF-I (HY-P7018). The purity of human IGF-I is greater than 95% as analyzed by SDS-PAGE under reducing (R) conditions.
Immune Checkpoint Proteins (690+)
The immune checkpoint (ICP) molecules refer to ligand-receptor pairs that exert inhibitory or stimulatory effect on immune responses. Some cancer cells can bind co-inhibitory receptor molecules to limit normal anti-tumor immune responses, thus assisting in immune escape. ICP therapy for cancer encompasses strategies that target regulatory pathways to reinvigorate the anti-tumor function of immune cells. A number of inhibitory immunoreceptors have been identified, including but not limited to PD-1, CTLA-4, LAG3, TIM3, TIGIT and BTLA.
CD Antigens (2260+)
Cluster of differentiation (CD) antigens frequently act as cell-cell or cell-matrix adhesion molecules, cytokine receptors, ionophores, or nutrient transporters. CD antigens are routinely used as cellular markers that can be used to identify and isolate the presence and proportion of specific leukocyte populations and lymphocyte subpopulations.
Fc Receptor Proteins (160+)
Receptors of the fragment crystalizable (Fc) portion of immunoglobulin (Fc receptors, FcRs) are membrane molecules that are expressed on most innate and adaptive immune cells. FcRs belong to the immunoglobulin superfamily and interact with the Fc portion of antibodies to link humoral immune responses to cellular effector mechanisms. Receptors for all classes of immunoglobulins include IgG (FcγRI/CD64, FcγRII/CD32, FcγRIII/CD16, and FcRn), IgE (FCεRI, FcεRII), IgA (FcαRI/CD89), IgM (FcμR), IgD (FcδR) and IgA/IgM (Fcα/μR).-
CAR-T Related Proteins (480+)
Chimeric antigen receptor T (CAR-T) cells, genetically engineered to express synthetic chimeric antigen receptors, can specifically target antigens and kill tumor cells. CAR-T cells can specifically recognize their target antigens through single-stranded fragment variant (scFv) binding domains, leading to T cells in a major histocompatibility complex (MHC)-independent manner activation. Therefore, in CAR design, antigen selection is critical for killing target tumor cells.
Custom Protein Services
MedChemExpress (MCE) provides a one-stop service from genes to proteins. Customers can flexibly choose services or personalized services according to their own needs.
One-stop service from gene design to protein preparation.
Independently developed high expression vectors and strains.
Professional R & D team of recombinant protein technology.
Providing customized services of high-purity protein from mg to g.
Large-scale protein production platform.
Information needed: Amino Acid Sequence
Final Delivery: Target proteins, Plasmid (optional), Project report or QC report
01. Except for a smaller number of expression high risk proteins, most proteins are risk-free customization: there is no charge if there is no expression, without any upfront payments.
02. The number of amino acids is not restricted, and specific proteins need to be explicitly evaluated.
03. If, due to the protein’s intrinsic properties, the quality and purity do not meet the requirements after attempts and there is no need to deliver the protein, only the prepaid fee (if any) will be charged.
04. Strict quality control is enforced, with default internal toxin levels at <1 EU/μg and purity greater than 90% (some proteins can reach more significant than 95%). If the estimated purity is below 90% due to protein characteristics, this will be communicated during evaluation, and the customer can decide whether to continue.