Navinci - Target Specific PLA Kits
Protein-Protein Interaction (PPI) Kits for PD1/PD-L1 and CD8/MHC-I detection
Naveni® PPI (Protein-Protein Interaction) Kits are target-specific in situ kits for detection of protein protein interactions in cultured cells, fresh-frozen, and FFPE samples. The primary antibody system with Navenibodies is included. No extra antibodies are needed. The assay is already optimized.
The Naveni® PPI kits are based on the Naveni® Proximity Ligation Technology.
Target-specific kits for manual PLA
Naveni Protein-Protein Interaction (PPI) kits
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Naveni® Plex - The first Multiplex PLA
With Naveni® Plex — the revolutionary in situ PLA multiplex solution — you can explore the intricate protein interactions within the tumor microenvironment.
Naveni® Plex is engineered to simultaneously detect:
- PD1/PD-L1 interactions – highlighting immune checkpoint pathways;
- CD8/MHC-I interactions – revealing T-cell activation;
- CD3 presence – tracking key T-cell markers.
Three pairs of Navenibodies are simultaneously incubated with your FFPE tissue sample to detect PD1–PD-L1, CD8–MHC-I, and two CD3 epitopes. Proximity triggers rolling circle amplification, producing strong FITC, Cy3, or Cy5 signals.
PD1/PD-L1 (magenta), CD3/CD3 (teal) and CD8/MHC-I (yellow) simultaneously detected by Naveni® Plex in (A) Hodgkin lymphoma, (B) lung cancer and (C) melanoma. Nuclei (DAPI) in grey.
Target-specific kits for automated PLA
NaveniBOND Protein-Protein Interaction kits
Naveni PD1/PD-L1
BOND RX HRP
Naveni PD1/PD-L1 BOND RX HRP is a fully automtatedin situ kit for precise visualization of the interaction of PD1/PD-L1 within the tissue microenvironment. Naveni PD1/PD-L1 BOND RX HRP is seamlessly integrated for chromogenic readout on the Leica BOND RX platform. Naveni PD1/PD-L1 BOND RX HRP is based on the cutting-edge Naveni® in situ proximity ligation technology. More
Naveni PD1/PDL1
BOND RX RED
Naveni PD1/PD-L1 BOND RX RED is a fully automtatedin situ kit for precise visualization of the interaction of PD1/PD-L1 within the tissue microenvironment. Naveni PD1/PD-L1 BOND RX RED is seamlessly integrated for Fluorescence readout (filterset suitable for Cy3,5) on the Leica BOND RX platform. Naveni PD1/PD-L1 BOND RX RED is based on the cutting-edge Naveni® in situ proximity ligation technology. More
Naveni PD1/PDL1
BOND RX Atto647N
Naveni PD1/PD-L1 BOND RX Atto647N is a fully automtatedin situ kit for precise visualization of the interaction of PD1/PD-L1 within the tissue microenvironment. Naveni PD1/PD-L1 BOND RX Atto647N is seamlessly integrated for Fluorescence readout (filterset suitable for Cy3,5) on the Leica BOND RX platform. Naveni PD1/PD-L1 BOND RX Atto647N is based on the cutting-edge Naveni® in situ proximity ligation technology. More
Naveni PD1/PD-L1
BOND RX HRP
Naveni PD1/PD-L1 BOND RX HRP is a fully automtatedin situ kit for precise visualization of the interaction of PD1/PD-L1 within the tissue microenvironment. Naveni PD1/PD-L1 BOND RX HRP is seamlessly integrated for chromogenic readout on the Leica BOND RX platform. Naveni PD1/PD-L1 BOND RX HRP is based on the cutting-edge Naveni® in situ proximity ligation technology. More
Naveni PD1/PDL1
BOND RX RED
Naveni PD1/PD-L1 BOND RX RED is a fully automtatedin situ kit for precise visualization of the interaction of PD1/PD-L1 within the tissue microenvironment. Naveni PD1/PD-L1 BOND RX RED is seamlessly integrated for Fluorescence readout (filterset suitable for Cy3,5) on the Leica BOND RX platform. Naveni PD1/PD-L1 BOND RX RED is based on the cutting-edge Naveni® in situ proximity ligation technology. More
Naveni PD1/PDL1
BOND RX Atto647N
Naveni PD1/PD-L1 BOND RX Atto647N is a fully automtatedin situ kit for precise visualization of the interaction of PD1/PD-L1 within the tissue microenvironment. Naveni PD1/PD-L1 BOND RX Atto647N is seamlessly integrated for Fluorescence readout (filterset suitable for Cy3,5) on the Leica BOND RX platform. Naveni PD1/PD-L1 BOND RX Atto647N is based on the cutting-edge Naveni® in situ proximity ligation technology. More
