PROGEN - AAV monitoring reagents

Monitor AAV identity, yield, potency, purity and integrity

PROGEN provides an exclusive and comprehensive portfolio of reagents for AAV monitoring, including AAV antibodies, AAV titration ELISA kits, AAV standards and density gradient media.

PROGEN is DIN EN ISO13485 certified and is made up of a team of experts within AAV and the life sciences and is partnered with gene therapy experts worldwide.

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AAV Antibodies

AAV Capsid Protein Antibodies

Analysis of denatured AAV capsid proteins
Detection of linear epitopes of the viral capsids VP1, VP2 and VP3 across serotypes

Applications: WB, IF/ICC, affinity chromatography, Dotblot, IP

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AAV Intact Particle Antibodies

Analysis of intact AAV particles, i.e. empty and full capsids
Detection of conformational epitope of the assembled capsid of certain serotypes

Applications: AAV ELISAs, IF/ICC, affinity chromatography, dot blot, IP, neutralization assay

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AAV Replicase Antibodies

Analysis of the regulatory proteins Rep78, Rep68, Rep52 and Rep40

Applications: Western Blot

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Human Chimeric AAV Antibodies

Testing patient sera before clinical trials ensures you know whether AAV antibodies are present in patient sera or not, resulting in a safe and efficient gene transfer.

Applications: Dot blot, neutralization assay, serology ELISA

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AAV ELISA

AAV Titration ELISAs

Titration of intact capsids
High precision and accuracy
Reliable serotype-specific positive controls for AAV ELISAs

Standard ELISA: 4.5h
Xpress ELISA: < 2h

Details | Order Standard ELISA | Order Xpress ELISA

Simple Plex™ Assays for Viral Quantification

Exclusively detect intact AAV capsids in bioprocess samples
Measure viral titer across a broad dynamic range
Quantify viral titer of AAV capsids
Hands free automation when using the Ella platform

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AAV Standards

AAV Empty Capsids

High viral particle titer
No additives and stabilizing proteins
Serotype-specific conformational epitopes
Suitable as positive control for a variety of applications

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AAV VP Capsid Protein Standards

Optimize your AAV production!

Monitor VP1, VP2, and VP3 protein concentrations and their molar ratios
Optimization of yield
Available for AAV2, AAV5, AAV6, AAV8 and AAV9

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AAV ELISA Controls

Can be used as positive controls with the corresponding AAV ELISAs
Independent controls to verify the test validity
They consist of fully assembled, empty AAV particles
Available for AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAVrh10 and AAVrh74

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Dip‘n‘Check AAV

Dip'n'Check AAV Lateral Flow Tests

Quick and easy in-process control
For the semi-quantitative detection of fully
Uses serotype-specific antibodies
assembled AAV capsids
For crude and purified material

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Density Gradient Medium - OptiPrep™

OptiPrep™

OptiPrep^TM is a ready-made, sterile and endotoxin-tested solution of iodixanol that works across research and clinical workflows, giving you control over your virus purification. Iodixanol can be used for full and empty capsid separation, as well as for AAV particle purification.

for AAV Particle Purification
for Full and Empty Capsid Separation

OptiPrep™ for AAV Particle Purification

OptiPrep™ for Full and Empty Capsid Separation

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