Cilengitide
| Catalog Number | Pack Size | List Price* | Quantity | |
|---|---|---|---|---|
| HY-16141-5MG | 5 mg | 181,00 | Add | |
| HY-16141-1ML | 10mM/1mL | 230,00 | Add | |
| HY-16141-10MG | 10 mg | 297,00 | Add | |
| HY-16141-S-1ST | Sample | Inquire |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
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Cilengitide (EMD 121974) is a potent integrins antagonist with IC50s of 0.61 nM (ανβ3), 8.4 nM (ανβ5) and 14.9 nM (α5β1), respectively. Cilengitide inhibits the binding of ανβ3 and ανβ5 to Vitronectin with IC50s of 4 nM and 79 nM, respectively. Cilengitide inhibits TGF-β/Smad signaling, mediates PD-L1 expression. Cilengitide also induces apoptosis, shows antiangiogenic effect in the research against glioblastoma and other cancers[1][2][3].
| Category | Biochemicals |
| Supplier | MedChem Express |
| Regulatory Status | RUO |
| Research Field | Cancer, Apoptosis,Autophagy,Cytoskeleton,Immunology/Inflammation,JAK/STAT Signaling,Stem Cell/Wnt |
| Format | Solubility: DMSO : ≥ 44 mg/mL;H2O : 100 mg/mL (ultrasonic) |
| Grade | Clinical information: Phase 3 |
| Purity | 99.8% |
| Molecular Formula | C27H40N8O7 |
| Molecular Weight | 588.66 |
| CAS-Number | 188968-51-6 |
| Storage Conditions | -20°C, 3 years (Powder) |
| Tech. Data Sheet | View datasheet |
| Link To Supplier | http://www.medchemexpress.com |
| Shipping Details | Blue Ice |
| Material Safety Data Sheet | Download PDF |
