Anti-HSP60 Monoclonal Antibody (Clone: LK1) - ATTO 594
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HSP90 is an abundantly and ubiquitously expressed heat shock protein. It is understood to exist in two principal forms alpha and beta, which share 85% sequence amino acid homology. The two isoforms of HSP90, are expressed in the cytosolic compartment. Despite the similarities, HSP90 alpha exists predominantly as a homodimer while HSP90 beta exists mainly as a monomer. From a functional perspective, HSP90 participates in the folding, assembly, maturation, and stabilization of specific proteins as an integral component of a chaperone complex. Furthermore, HSP90 is highly conserved between species; having 60% and 78% amino acid similarity between mammalian and the corresponding yeast and Drosophila proteins, respectively.HSP90 is a highly conserved and essential stress protein that is expressed in all eukaryotic cells. Despite its label of being a heat-shock protein, HSP90 is one of the most highly expressed proteins in unstressed cells (12% of cytosolic protein). It carries out a number of housekeeping functions including controlling the activity, turnover, and trafficking of a variety of proteins. Most of the HSP90-regulated proteins that have been discovered to date are involved in cell signaling. The number of proteins now know to interact with HSP90 is about 1
|Application||WB, IHC, IP, EL|
|Immunogen||Recombinant human HSP60|
|Crossreactivity||Hu, Ms, Rt, Bo, Dg, Ck, Drosophila, Gp , Mk, Pg, Rb, Sh|
|Working Dilution||WB (1:20000), IHC (1:100), ICC/IF (1:100), IP (1:200); optimal dilutions for assays should be det...|
|Purity||Protein G Purified|
|Storage Conditions||Store the antibody at 4°C|
|Tech. Data Sheet||View datasheet|
|Link To Supplier||https://www.abeomics.com|
|Shipping Details||Blue Ice|
|Material Safety Data Sheet||Download PDF|