Poloppin
| Catalog Number | Pack Size | List Price* | Quantity | |
|---|---|---|---|---|
| HY-124761-1ST | Get quote | Inquire |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
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Poloppin is a potent, cell penetrant inhibitor of the mitotic Polo-like kinase (PLK) (IC50=26.9 μM) and prevents the protein-protein interaction via the Polo-box domain (PBD) (Kd= 29.5 μM). Poloppin selectively kills cells expressing mutant KRAS, enhancing death in mitosis. Poloppin is used for the study of KRAS-mutant cancers as single agents, or in combination with c-MET inhibitors[1].
| Category | Biochemicals |
| Supplier | MedChem Express |
| Regulatory Status | RUO |
| Research Field | Cancer, Autophagy,Cell Cycle/DNA Damage |
| Format | Solubility: 10 mM in DMSO |
| Grade | Clinical information: No Development Reported |
| Molecular Formula | C20H15BrF3NO2 |
| Molecular Weight | 438.24 |
| CAS-Number | 683808-78-8 |
| Tech. Data Sheet | View datasheet |
| Link To Supplier | http://www.medchemexpress.com |
| Shipping Details | Room temperature |
| Material Safety Data Sheet | Download PDF |
