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FK706 is a potent, slow-binding and competitive inhibitor of human neutrophil elastase with an IC50 of 83 nM and a Ki of 4.2 nM. FK706 also inhibits mouse neutrophil elastase and porcine pancreatic elastase with IC50s of 22 nM and 100 nM, respectively, and has no inhibitory activity against other serine proteinases such as human pancreatic trypsin, human pancreatic α-chymotrypsin and human leukocyte cathepsin G. FK706 has anti-inflammatory effect.
|Format||Solubility: DMSO : 115 mg/mL (194.08 mM; Need ultrasonic)|
|Grade||Clinical information: No Development Reported|
|Storage Conditions||4°C, protect from light; In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)|
|Tech. Data Sheet||View datasheet|
|Link To Supplier||http://www.medchemexpress.com|
|Material Safety Data Sheet||Download PDF|