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SignalChem Diagnostics - Raw materials for diagnostic tests
Proteins, enzymes and compounds suitable for the development of IVDs
In vitro diagnostics (IVD) raw materials are indispensable components that enable the creation of precise, efficient, and dependable diagnostic tests and assays. In addition, they equip researchers with the power to identify diseases earlier, monitor patients‘ health, and make well-informed treatment decisions, leading to life-altering diagnostic tools. IVD raw materials pave the way for personalized medicine, promoting accurate diagnoses and informed treatment choices.
SignalChem Diagnostics, a subsidiary of SignalChem Lifesciences, is exclusively focussing on the development and production of raw materials – such as proteins, enzymes, compounds, reagents – for usage in the development of diagnostic tests, other diagnostics, therapeutics, vaccine development, drug discovery etc.
SignalChem Diagnostics provides a comprehensive and growing product range of IVD raw materials including CRISPR associated proteins, Allergens, Molecular diagnostic related proteins, Clinical Chemistry and COVID-19 related products.
CRISPR Associated Proteins and Products
CRISPR Associated Enzymes
CRISPR-associated proteins, featuring a diverse range of highly active CRISPR enzymes with exceptional specificity, efficiency, and versatility.
CRISPR Associated Reagents
Reaction and storage buffers, carefully formulated to maintain enzyme activity, maximize efficiency, and ensure reliable results.
Custom Guide RNAs
Expertly synthesized and tailored custom guide RNAs for a wide range of research applications.
Featured CRISPR products
AapCas12b, Active
(C12B1-E311U)
AapCas12b belongs to the type V CRISPR effector, CRISPR-Cas12b/C2c1, and due to its thermostability, it can be used in a wide range of biomedical applications including loop-mediated isothermal amplification (LAMP), mammalian genome editing, and gene activation. Details
Purity
Activity
EiCsm6, Active
(CS06-E312H)
EiCsm6 is an ancillary ribonuclease associated with the type III CRISPR-Cas system of Enterococcus italicus. EiCsm6 consists of a CARF (CRISPR associated Rossman fold) domain which binds cyclic oligoadenylate (cOA) and a HEPN domain which possesses ribonuclease activity. Details
Purity
Activity
SpCas9-NLS, Active
(CS09N-E312H)
Recombinant full length Cas9-NLS from S. pyogenes was expressed in E. coli using a C-terminal His tag. Cas9-NLS contains a nuclear localization sequence for optimal activity. Cas9 can be used for genetic engineering experiments such as genome editing and generating transgenic models. Details
Purity
Activity
TtCsm6, Active
(CS06-E311H)
Upon activation of the CRISPR ancillary ribonucleases Csx1/Csm6, the HEPN active site degrades invasive RNA non-specifically. TtCsm6 is activated by the cyclic oligoadenylate second messengers that was converted from ATP by the Cas10 subunit of the Type III interference complex. Details
Purity
Activity
Immunodiagnostics, Allergens
Antibodies
High-quality monoclonal antibodies targeting Human IgA, IgG, and IgM. Exceptional specificity and sensitivity. Designed for immunodiagnostic assays. Reliable performance in ELISA, Western blot, immunoprecipitation, and others.
Purified Allergens
Purified allergens designed for immunodiagnostic assays and covering various allergen sources, including molds, pollens, mites, and animal allergens. Optimized for use in ELISA, lateral flow tests, and immunoblotting.
Featured Allergen Products
Molecular Diagnostic Related Products
Enzymes
High-quality molecular enzymes including enzymes for efficient cDNA synthesis, reliable PCR amplification, and accurate qPCR analysis. Carefully optimized and rigorously tested for consistent results. Ideal for molecular diagnostic assays.
Isothermal Amplification Enzymes
The high-quality isothermal enzymes include DNA polymerases, helicases, and recombinases, facilitating the efficient and accurate manipulation of nucleic acids in a variety of molecular techniques.
Clinical Chemistry
Enzymes
Enzymes for clinical chemistry applications in diagnostic tests and assays. Rigorously tested for accuracy, sensitivity, and consistency, enabling precise quantification and detection of analytes.
Co-Factors
Rigorously tested Co-factors (NAD, NADH, NADP-H, NMN, Thio-NAD) ensuring reliable and accurate detection of analytes. Contributing to enhanced sensitivity and specificity in various diagnostic tests.
Covid-19 Related Products
Proteins
Includes various forms of the SARS-CoV-2 Spike protein, Nucleocapsid protein, non-structural proteins (NSPs), and key enzymes, as well as human proteins involved in virus-host interactions.
Inhibitors
COVID-19 inhibitor compounds with demonstrated potential in targeting various aspects of the SARS-CoV-2 replication cycle or modulating host immune responses. Ideal to investigate the efficacy, safety, and mechanism of action of potential therapeutic candidates.
Antibodies
Includes human and mouse monoclonal antibodies against SARS-CoV-2 viral proteins such as the Spike and Nucleocapsid proteins, as well as antibodies targeting specific viral mutations.
Nanobodies
COVID-19 neutralizing nanobodies, engineered to target the SARS-CoV-2 Spike protein, effectively neutralizing viral entry into host cells. High specificity, stability, and ease of production. Valuable tools for understanding virus-host interactions and developing potential therapeutics.
Cell Lines
COVID-19 cell lines to study virus-host interactions, assess antiviral efficacy, and conduct large-scale screenings in a safe and controlled environment.
Assay Kits, ELISA Kits
SARS-CoV-2 ELISA kits for detection and quantification of SARS-CoV-2 spike protein (RBD) and human anti-SARS-CoV-2 spike protein IgG in biological and recombinant samples.
General Reagents
Essential laboratory components designed to support a variety of scientific applications including enzymes, buffers, and other high-quality products that play a pivotal role in facilitating accurate and reliable experimental outcomes. Rigorous quality control processes ensure superior performance and reproducibility.
