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SignalChem Diagnostics - Raw materials for diagnostic tests

Proteins, enzymes and compounds suitable for the development of IVDs

In vitro diagnostics (IVD) raw materials are indispensable components that enable the creation of precise, efficient, and dependable diagnostic tests and assays. In addition, they equip researchers with the power to identify diseases earlier, monitor patients‘ health, and make well-informed treatment decisions, leading to life-altering diagnostic tools. IVD raw materials pave the way for personalized medicine, promoting accurate diagnoses and informed treatment choices. 

SignalChem Diagnostics, a subsidiary of SignalChem Lifesciences, is exclusively focussing on the development and production of raw materials – such as proteins, enzymes, compounds, reagents – for usage in the development of diagnostic tests, other diagnostics, therapeutics, vaccine development, drug discovery etc. 

SignalChem Diagnostics provides a comprehensive and growing product range of IVD raw materials including CRISPR associated proteins, Allergens, Molecular diagnostic related proteins, Clinical Chemistry and COVID-19 related products.


CRISPR Associated Proteins and Products

CRISPR Associated Enzymes

CRISPR-associated proteins, featuring a diverse range of highly active CRISPR enzymes with exceptional specificity, efficiency, and versatility.

CRISPR Associated Reagents

Reaction and storage buffers, carefully formulated to maintain enzyme activity, maximize efficiency, and ensure reliable results.

Custom Guide RNAs

Expertly synthesized and tailored custom guide RNAs for a wide range of research applications.

Featured CRISPR products

AapCas12b, Active

AapCas12b belongs to the type V CRISPR effector, CRISPR-Cas12b/C2c1, and due to its thermostability, it can be used in a wide range of biomedical applications including loop-mediated isothermal amplification (LAMP), mammalian genome editing, and gene activation. Details

AapCas12b Purity
AapCas12b Activity

EiCsm6, Active

EiCsm6 is an ancillary ribonuclease associated with the type III CRISPR-Cas system of Enterococcus italicus. EiCsm6 consists of a CARF (CRISPR associated Rossman fold) domain which binds cyclic oligoadenylate (cOA) and a HEPN domain which possesses ribonuclease activity. Details

EiCsm6 Purity
EiCsm6 Activity

SpCas9-NLS, Active

Recombinant full length Cas9-NLS from S. pyogenes was expressed in E. coli using a C-terminal His tag. Cas9-NLS contains a nuclear localization sequence for optimal activity. Cas9 can be used for genetic engineering experiments such as genome editing and generating transgenic models. Details

SpCas9-NLS Purity
SpCas9-NLS Activity

TtCsm6, Active

Upon activation of the CRISPR ancillary ribonucleases Csx1/Csm6, the HEPN active site degrades invasive RNA non-specifically. TtCsm6 is activated by the cyclic oligoadenylate second messengers that was converted from ATP by the Cas10 subunit of the Type III interference complex. Details

TtCsm6 Activity
TtCsm6 Purity
Allergens icon

Immunodiagnostics, Allergens


High-quality monoclonal antibodies targeting Human IgA, IgG, and IgM. Exceptional specificity and sensitivity. Designed for immunodiagnostic assays. Reliable performance in ELISA, Western blot, immunoprecipitation, and others.

Purified Allergens

Purified allergens designed for immunodiagnostic assays and covering various allergen sources, including molds, pollens, mites, and animal allergens. Optimized for use in ELISA, lateral flow tests, and immunoblotting.

Featured Allergen Products

Asp f 6 - Aspergillus fumigatus

Recombinant full-length Aspergillus fumigatus allergen Asp f 6 was expressed in E. coli using a C-terminal His tag. Details

Asp f 6 Purity

Can f 3 - Canis familiaris

Recombinant full-length Canis familiaris major allergen Can f 3 was expressed in E.coli using a C-terminal His tag. Details

Can f 3 Purity

Der f 1 - Dermatophagoides farinae

Recombinant full-length Dermatophagoides farinae allergen Der f 1 was expressed in E coli using a C-terminal His tag. Details

Der f 1 Purity

Pen ch 18 - Penicillium chrysogenum

Recombinant Penicillium chrysogenum allergen Pen ch 18 was expressed in E. coli using a C-terminal His tag. Details

Pen ch 18 Purity
Molecular Biology icon

Molecular Diagnostic Related Products


High-quality molecular enzymes including enzymes for efficient cDNA synthesis, reliable PCR amplification, and accurate qPCR analysis. Carefully optimized and rigorously tested for consistent results. Ideal for molecular diagnostic assays.

Isothermal Amplification Enzymes

The high-quality isothermal enzymes include DNA polymerases, helicases, and recombinases, facilitating the efficient and accurate manipulation of nucleic acids in a variety of molecular techniques.

Clinical Chemistry icon

Clinical Chemistry


Enzymes for clinical chemistry applications in diagnostic tests and assays. Rigorously tested for accuracy, sensitivity, and consistency, enabling precise quantification and detection of analytes.


Rigorously tested Co-factors (NAD, NADH, NADP-H, NMN, Thio-NAD) ensuring reliable and accurate detection of analytes. Contributing to enhanced sensitivity and specificity in various diagnostic tests. 

COVID icon

Covid-19 Related Products


Includes various forms of the SARS-CoV-2 Spike protein, Nucleocapsid protein, non-structural proteins (NSPs), and key enzymes, as well as human proteins involved in virus-host interactions.


COVID-19 inhibitor compounds with demonstrated potential in targeting various aspects of the SARS-CoV-2 replication cycle or modulating host immune responses. Ideal to investigate the efficacy, safety, and mechanism of action of potential therapeutic candidates.


Includes human and mouse monoclonal antibodies against SARS-CoV-2 viral proteins such as the Spike and Nucleocapsid proteins, as well as antibodies targeting specific viral mutations.


COVID-19 neutralizing nanobodies, engineered to target the SARS-CoV-2 Spike protein, effectively neutralizing viral entry into host cells. High specificity, stability, and ease of production. Valuable tools for understanding virus-host interactions and developing potential therapeutics.

Cell Lines

COVID-19 cell lines to study virus-host interactions, assess antiviral efficacy, and conduct large-scale screenings in a safe and controlled environment.

Assay Kits, ELISA Kits

SARS-CoV-2 ELISA kits for detection and quantification of SARS-CoV-2 spike protein (RBD) and human anti-SARS-CoV-2 spike protein IgG in biological and recombinant samples.

General Reagents icon

General Reagents

Essential laboratory components designed to support a variety of scientific applications including enzymes, buffers, and other high-quality products that play a pivotal role in facilitating accurate and reliable experimental outcomes. Rigorous quality control processes ensure superior performance and reproducibility.